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U.S. stocks were mostly flat Tuesday as the major indexes looked to build on record highs in the final week of the year.

The Dow Jones Industrial Average traded up 0.1%. The S&P 500 gained less than 0.1%. The Nasdaq Composite was flat.

The move in futures comes after stocks rallied in Monday’s regular session, with the S&P 500 closing at its 69th record high of the year.

Markets continued to look to pandemic news for direction.

The Centers for Disease Control and Prevention announced on Monday that it was shortening its isolation recommendation for people who test positive to five days from 10, if those people do not have symptoms.

Research out of South Africa also indicated that omicron infections can help boost immunity to the earlier delta strain of Covid.

Pharmaceutical stocks dipped in early trading following the relatively optimistic news on the pandemic. Moderna slipped 1.1% and Pfizer was marginally lower in light premarket trading Tuesday morning.

Stocks dipped in late November, in part because of the rise of the omicron variant of Covid-19, but have since rebounded as governments have largely shied away from reinstating lockdowns and strict social distancing measures.

Stocks tend to rise in light trading during the final days of the year, often called the “Santa Claus rally.” However, many Wall Street pros predict relatively small gains for stocks in 2022 after two strong years.

“If you look around Wall Street, you see very tame expectations, and it’s probably a reflection that we’re probably pretty late in the cycle,” Jim Lacamp, senior vice president at Morgan Stanley Wealth Management, said on “Closing Bell.”

For the year, the S&P 500 is up 27.6% for the year and the Nasdaq is up 23.1%. The Dow is the laggard, up 18.6%.