Mounjaro心血管保护效果未超越Trulicity！礼来(LLY.US)令市场失望_老虎社区_美港股上老虎

Mounjaro心血管保护效果未超越Trulicity！礼来(LLY.US)令市场失望

智通财经2025-07-31

智通财经APP获悉，礼来(LLY.US)的明星糖尿病药物Mounjaro在一项针对两种治疗方法的正面对比研究中显示，其在预防心脏病发作和中风方面的效果与该公司老牌药物Trulicity基本相当。这项迄今为止礼来针对Mounjaro开展的规模最大、历时最长的试验，原本旨在证明该药物在降低主要心血管事件风险方面"不劣于"Trulicity，即希望表明Mounjaro是可接受的替代治疗方案。虽然达到了这...

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·2025-07-31
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href=http://www.zhitongcaijing.com/content/detail/1324416.html><strong>智通财经</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>智通财经APP获悉，礼来(LLY.US)的明星糖尿病药物Mounjaro在一项针对两种治疗方法的正面对比研究中显示，其在预防心脏病发作和中风方面的效果与该公司老牌药物Trulicity基本相当。这项迄今为止礼来针对Mounjaro开展的规模最大、历时最长的试验，原本旨在证明该药物在降低主要心血管事件风险方面\"不劣于\"Trulicity，即希望表明Mounjaro是可接受的替代治疗方案。虽然达到了这...</p>\n\n<a href=\"http://www.zhitongcaijing.com/content/detail/1324416.html\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU1974910355.USD","symbol_name":"Allianz Thematica Cl AMg DIS 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Eli Lilly (LLY.US) Disappoints Markets","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"LLY":1},"content_text":"智通财经APP获悉，礼来(LLY.US)的明星糖尿病药物Mounjaro在一项针对两种治疗方法的正面对比研究中显示，其在预防心脏病发作和中风方面的效果与该公司老牌药物Trulicity基本相当。这项迄今为止礼来针对Mounjaro开展的规模最大、历时最长的试验，原本旨在证明该药物在降低主要心血管事件风险方面\"不劣于\"Trulicity，即希望表明Mounjaro是可接受的替代治疗方案。虽然达到了这一目标，但研究结果打破了投资者对Mounjaro显著优于老药的期待。分析师迈克尔·沙阿表示，\"完全没有提及优效性——而礼来也确实进行了这项测试，\"\"因此市场反应可能会很消极。\"礼来的股价在纽约盘前交易中一度下跌5.3%，截至发稿，其跌幅收窄至1%。这项试验纳入了13,000多名患有2型糖尿病且有心脏病史的患者，平均随访约四年期间，受试者分别接受Mounjaro或Trulicity治疗。礼来周四公布的结果显示，Mounjaro能有效降低心梗、中风和心血管死亡风险，但效果并未显著优于老药Trulicity。Mounjaro在其他健康指标上表现更佳。与Trulicity组相比，该药物使用者的全因死亡率低16%。礼来表示，Mounjaro组患者在血糖控制、减重和降压方面改善更明显。两种药物最常见的不良反应均为轻度胃肠道症状。Mounjaro使用者减重更多但心血管风险降幅相当的现象表明，这类被称为GLP-1的药物可能具有独立于减重效果的心脏保护作用。礼来将于9月在医学会议上公布完整研究，并计划年底前向全球药监机构提交新数据，以寻求将降低心血管风险纳入Mounjaro的适应症。礼来心血管代谢业务总裁肯·卡斯特在声明中表示，\"这些发现强化了Mounjaro作为2型糖尿病合并心血管疾病患者一线治疗选择的潜力。\"Trulicity早在2020年就获得美国监管部门批准用于降低2型糖尿病患者主要心血管事件风险。礼来与竞争对手诺和诺德正竞相拓展旗下药物在糖尿病和减肥之外的适应症研究。虽然多数保险公司承保糖尿病治疗，但许多机构不愿覆盖减肥用途。诺和诺德已证实Ozempic和Wegovy均可降低肥胖和糖尿病患者的心血管事件风险，相关适应症标签使其在与保险机构和政府医保谈判中占据优势。不过，即便未获批心血管适应症，礼来仍从诺和诺德手中夺取了可观市场份额。该公司并未专门针对减肥药Zepbound开展心血管风险研究，而是通过一项长达数年的大型试验评估其降低全因死亡率的效果，最终数据预计要到2027年才能出炉。","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"-1","news_tag":"","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"},"commentList":[{"id":462688874021192,"gmtCreate":1753967014770,"gmtModify":1753967016408,"author":{"id":"3471744263113398","authorId":"3471744263113398","name":"稳稳稳稳稳","avatar":"https://static.laohu8.com/default-avatar.jpg","vip":1,"crmLevel":1,"crmLevelSwitch":0,"idStr":"3471744263113398","authorIdStr":"3471744263113398"},"htmlText":"胡说八道呀","listText":"胡说八道呀","text":"胡说八道呀","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":1,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/462688874021192","repostId":2555388898,"repostType":2,"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"CN"}],"hasMoreComments":true,"newsSizeData":{"likeSize":0,"commentSize":1,"repostSize":1,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"isCrawlerRequest":true}