成都先导与辉瑞合作开发出适用于DEL的异喹诺酮骨架合成方法_老虎社区_美港股上老虎

成都先导与辉瑞合作开发出适用于DEL的异喹诺酮骨架合成方法

证券时报网04-26

证券时报e公司讯，据成都先导消息，近日，成都先导与辉瑞公司在适用于DNA编码化合物库(DNA-Encodedlibrary，DEL)的异喹诺酮骨架合成方法探索上取得重要突破——通过三价铑催化的碳氢活化反应成功实现了DNA上异喹诺酮骨架的关环。进一步实验证明该方法能够用于DEL的合成。该方法条件温和，底物适用性广，提供了更多的分子多样性。

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