中原狙神的个人主页 - 老虎社区

中原狙神

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2020-06-11

$梅西百货(M)$每天跌10个点，这他妈谁扛的住[喷血]

2021-11-16

$挪威邮轮(NCLH)$啥情况，崩盘了[无语]

2021-08-21

$RLX科技(RLX)$$好未来(TAL)$$高途(GOTU)$30干到3块，比肩教育三傻，年度最惨的票

2021-02-19

$快手-W(01024)$顶多值200，机构硬炒到400[无语]

2021-10-26

$老虎证券(TIGR)$竟然有如此垃🐔，毫无底线[无语] ，把大A的恶庄手法体现的淋漓尽致

2021-12-03

$老虎证券(TIGR)$$滴滴(DIDI)$$拼多多(PDD)$滴滴携手中概股集体退市，大家散了吧，回大A玩了

2021-10-15

$老虎证券(TIGR)$2块见吧，还能说啥子[喷血] [喷血] [喷血]

2021-09-24

$老虎证券(TIGR)$摇摇欲坠，随时10块

2021-01-06

$C3.ai, Inc.(AI)$机构目标200，结果干回100[捂脸]

2021-09-24

$老虎证券(TIGR)$$腾讯音乐(TME)$中概股真人让🥚疼，一个像样的反弹都没有

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皇家都回到疫情新高了，你还在底部墨迹[喷血]","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":3,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/249183296069888","isVote":1,"tweetType":1,"viewCount":2299,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":223652216479928,"gmtCreate":1695639080350,"gmtModify":1695639081818,"author":{"id":"3525666228690124","authorId":"3525666228690124","name":"中原狙神","avatar":"https://static.laohu8.com/default-avatar.jpg","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3525666228690124","idStr":"3525666228690124"},"themes":[],"htmlText":"败家玩意，一顿造","listText":"败家玩意，一顿造","text":"败家玩意，一顿造","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/223652216479928","repostId":"1118657861","repostType":2,"repost":{"id":"1118657861","kind":"news","pubTimestamp":1695638573,"share":"https://www.laohu8.com/m/news/1118657861?lang=zh_CN&edition=full","pubTime":"2023-09-25 18:42","market":"sg","language":"zh","title":"传蔚来计划向投资者融资30亿美元！公司发公告澄清传闻","url":"https://stock-news.laohu8.com/highlight/detail?id=1118657861","media":"华尔街见闻","summary":"2016年至今年上半年，蔚来的累计净亏损达到630.82亿元。","content":"<html><head></head><body><p>周一，<a href=\"https://laohu8.com/S/NIO\">蔚来</a>盘前直线下挫，截至发稿跌幅超7%。媒体援引知情人士消息称：<strong>因亏损不断扩大，<a href=\"https://laohu8.com/S/NIO.SI\">蔚来</a>计划向投资者融资30亿美元。</strong></p><p class=\"t-img-caption\"><img src=\"https://static.tigerbbs.com/37dbfda38442f06035ae840da8d2a348\" title=\"\" tg-width=\"450\" tg-height=\"130\"/></p><p>蔚来公告，公司已注意到部分媒体的猜测，声称公司正在考虑向投资者筹集部分资金。鉴于今日公司美国存托股份的异常市场活动，公司希望澄清，除于2023年9月25日完成的可转换优先债券发行外，公司目前没有任何应报告的融资活动。</p><p class=\"t-img-caption\"><img src=\"https://static.tigerbbs.com/3308598008c418fa779deb6931c53b23\" tg-width=\"1104\" tg-height=\"395\"/></p><p>就在6月20日，蔚来与阿布扎比投资机构CYVN Holdings签订股份认购协议。根据协议，CYVN Holdings将通过定向增发新股和老股转让的方式向蔚来进行总计约11亿美元的战略投资。</p><p style=\"text-align: justify;\">今年二季度，蔚来实现了营业收入87.7亿元，同比下降14.8%，环比下降17.8%，低于市场预期的91.5亿元；净亏损仍处于扩大趋势中，达到60.56亿元，同比增长119.6%，环比增长27.8%；毛利率尚未转负，但是仍处于下滑态势，同比降低12个百分点。据统计，2016年至今年上半年，蔚来的累计净亏损达到630.82亿元。</p><p style=\"text-align: justify;\">作为蔚小理中唯一一家，在二季度销量出现同环比下滑的造车新势力，直接影响了二季度业绩。不仅整体营收重回下行区间，低于市场预期，净亏损更是进一步扩大。</p><p style=\"text-align: justify;\">有分析指出，备受市场关注的蔚来手机有望在9月下旬就进行交付，和蔚来汽车产品进行车机互联，有利于增加车的竞争力。</p><p style=\"text-align: justify;\">9月21日举行的NIO IN 2023 蔚来<a href=\"https://laohu8.com/S/C76.SI\">创新科技</a>日上，蔚来手机终于揭开了神秘面纱。除了常规的处理器、屏幕、影像等内容，备受外界期待的NIO Phone最大的亮点莫过于其与蔚来汽车的互联技术。</p><p style=\"text-align: justify;\">不过，即便NIO Phone被誉为“为蔚来车主而生的手机”，但其定价并不算亲民，6499元的起售价甚至比华为Mate 60 12GB+512GB的售价还高出500元，因此对于花6499元买一个“车钥匙”手机，不少网友仍持观望态度。</p><p style=\"text-align: justify;\">在多位市场人士看来，手机市场有<a href=\"https://laohu8.com/S/AAPL\">苹果</a>、华为、小米这样的巨头，蔚来想要靠卖手机“补血”，可能性并不大。</p></body></html>","source":"live_wallstreetcn","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>传蔚来计划向投资者融资30亿美元！公司发公告澄清传闻</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; 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overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\n传蔚来计划向投资者融资30亿美元！公司发公告澄清传闻\n</h2>\n\n<h4 class=\"meta\">\n\n\n2023-09-25 18:42 北京时间&nbsp;&nbsp;&nbsp;<a href=https://wallstreetcn.com/articles/3698606><strong>华尔街见闻</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>周一，蔚来盘前直线下挫，截至发稿跌幅超7%。媒体援引知情人士消息称：因亏损不断扩大，蔚来计划向投资者融资30亿美元。蔚来公告，公司已注意到部分媒体的猜测，声称公司正在考虑向投资者筹集部分资金。鉴于今日公司美国存托股份的异常市场活动，公司希望澄清，除于2023年9月25日完成的可转换优先债券发行外，公司目前没有任何应报告的融资活动。就在6月20日，蔚来与阿布扎比投资机构CYVN Holdings签订...</p>\n\n<a href=\"https://wallstreetcn.com/articles/3698606\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"https://static.tigerbbs.com/608c0ca7f544a93854339353ff5e9ae1","relate_stocks":{"EVS.SI":"MSCI China Electric Vehicles and Future Mobility ETF-NikkoAM","09866":"蔚来-SW","LU0052750758.USD":"富兰克林中国基金A Acc","BK4099":"汽车制造商","LU0320764599.SGD":"FTIF - Templeton China A Acc SGD","BK4526":"热门中概股","BK4585":"ETF&股票定投概念","LU0708995583.HKD":"TEMPLETON CHINA \"A\" (HKD) ACC","BK4555":"新能源车","NIO":"蔚来","BK4505":"高瓴资本持仓","BK4504":"桥水持仓","NIO.SI":"蔚来","BK1119":"汽车制造商","BK4588":"碎股","BK4548":"巴美列捷福持仓","BK4574":"无人驾驶","BK4509":"腾讯概念","BK1588":"回港中概股","BK4532":"文艺复兴科技持仓"},"source_url":"https://wallstreetcn.com/articles/3698606","is_english":false,"share_image_url":"https://static.laohu8.com/cc96873d3d23ee6ac10685520df9c100","article_id":"1118657861","content_text":"周一，蔚来盘前直线下挫，截至发稿跌幅超7%。媒体援引知情人士消息称：因亏损不断扩大，蔚来计划向投资者融资30亿美元。蔚来公告，公司已注意到部分媒体的猜测，声称公司正在考虑向投资者筹集部分资金。鉴于今日公司美国存托股份的异常市场活动，公司希望澄清，除于2023年9月25日完成的可转换优先债券发行外，公司目前没有任何应报告的融资活动。就在6月20日，蔚来与阿布扎比投资机构CYVN Holdings签订股份认购协议。根据协议，CYVN Holdings将通过定向增发新股和老股转让的方式向蔚来进行总计约11亿美元的战略投资。今年二季度，蔚来实现了营业收入87.7亿元，同比下降14.8%，环比下降17.8%，低于市场预期的91.5亿元；净亏损仍处于扩大趋势中，达到60.56亿元，同比增长119.6%，环比增长27.8%；毛利率尚未转负，但是仍处于下滑态势，同比降低12个百分点。据统计，2016年至今年上半年，蔚来的累计净亏损达到630.82亿元。作为蔚小理中唯一一家，在二季度销量出现同环比下滑的造车新势力，直接影响了二季度业绩。不仅整体营收重回下行区间，低于市场预期，净亏损更是进一步扩大。有分析指出，备受市场关注的蔚来手机有望在9月下旬就进行交付，和蔚来汽车产品进行车机互联，有利于增加车的竞争力。9月21日举行的NIO IN 2023 蔚来创新科技日上，蔚来手机终于揭开了神秘面纱。除了常规的处理器、屏幕、影像等内容，备受外界期待的NIO Phone最大的亮点莫过于其与蔚来汽车的互联技术。不过，即便NIO Phone被誉为“为蔚来车主而生的手机”，但其定价并不算亲民，6499元的起售价甚至比华为Mate 60 12GB+512GB的售价还高出500元，因此对于花6499元买一个“车钥匙”手机，不少网友仍持观望态度。在多位市场人士看来，手机市场有苹果、华为、小米这样的巨头，蔚来想要靠卖手机“补血”，可能性并不大。","news_type":1,"symbols_score_info":{"NIO.SI":0.6,"EVS.SI":0.6,"09866":1,"NIO":1}},"isVote":1,"tweetType":1,"viewCount":2624,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":222155485384736,"gmtCreate":1695268715857,"gmtModify":1695268717338,"author":{"id":"3525666228690124","authorId":"3525666228690124","name":"中原狙神","avatar":"https://static.laohu8.com/default-avatar.jpg","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3525666228690124","idStr":"3525666228690124"},"themes":[],"htmlText":"车都还没造明白，还搞手机[喷血]&nbsp;&nbsp;","listText":"车都还没造明白，还搞手机[喷血]&nbsp;&nbsp;","text":"车都还没造明白，还搞手机[喷血]","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/222155485384736","repostId":"1196669385","repostType":2,"repost":{"id":"1196669385","kind":"news","pubTimestamp":1695266053,"share":"https://www.laohu8.com/m/news/1196669385?lang=zh_CN&edition=full","pubTime":"2023-09-21 11:14","market":"us","language":"zh","title":"蔚来手机发布！NIO Phone起售价6499元，9月28日开始交付","url":"https://stock-news.laohu8.com/highlight/detail?id=1196669385","media":"新浪科技 ","summary":"9月21日上午，在今日的NIO IN 2023蔚来创新科技日上，蔚来创始人、董事长、CEO李斌发表演讲。会上，蔚来手机NIOPhone正式亮相。对于为什么要做手机，李斌表示，不是因为手机公司都在造车，也不是因为蔚来造车不赚钱要用手机盈利，而是蔚来用户需要一款与蔚来汽车无缝连接的手机。他表示，蔚来手机NIOPhone定位是一部旗舰手机，搭载高通骁龙8Gen2领先版，最高16GB+1T内存组合可选。配备6.81英寸屏幕，支持1-120Hz可变刷新率，搭载5000万广角+超广角+潜望长焦后置三摄。","content":"<html><head></head><body><blockquote><p></p><p><strong>蔚来发布旗舰手机NIO Phone，分为“性能版”、“旗舰版”、“EPedition”三个版本，售价分别为6499元、6899元、7499元。</strong></p></blockquote><p>9月21日上午，在今日的NIO IN 2023蔚来创新科技日上，蔚来创始人、董事长、CEO李斌发表演讲。</p><p class=\"t-img-caption\"><img src=\"https://static.tigerbbs.com/f05bfe1084e799daa79a8850c932a6cc\" title=\"\" tg-width=\"550\" tg-height=\"353\"/></p><p style=\"text-align: start;\">会上，蔚来手机NIOPhone正式亮相。对于为什么要做手机，李斌表示，不是因为手机公司都在造车，也不是因为蔚来造车不赚钱要用手机盈利，而是蔚来用户需要一款与蔚来汽车无缝连接的手机。</p><p style=\"text-align: start;\">他表示，蔚来手机NIOPhone定位是一部旗舰手机，搭载高通骁龙8Gen2领先版，最高16GB+1T内存组合可选。</p><p style=\"text-align: start;\">配备6.81英寸屏幕，支持1-120Hz可变刷新率，搭载5000万广角+超广角+潜望长焦后置三摄。</p><p><img src=\"https://static.tigerbbs.com/517d665dcbee9f65fd2692ec7a829df5\" alt=\"\"/><strong>蔚来NIO Phone发布，起售价6499元，将于9月28日开始交付</strong></p><p>蔚来发布旗舰手机NIO Phone，分为“性能版”、“旗舰版”、“EPedition”三个版本，售价分别为6499元、6899元、7499元，将于9月28日开始交付。</p><p>硬件方面，该款手机将搭载高通骁龙8 Gen2处理器，配备6.81英寸屏幕支持120Hz高刷，搭载后置三摄，最高可选 16GB + 1TB 存储；软件方面，搭载基于安卓系统的SKY UI，并且零广告、零预装App，支持30项功能通过“车控键”一键直达。</p><p></p><p class=\"t-img-caption\"><img src=\"https://static.tigerbbs.com/f7bf4de57d1b73465b979eec75a271ad\" title=\"\" tg-width=\"1529\" tg-height=\"1147\"/></p></body></html>","source":"lsy1635144614083","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta 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IN 2023蔚来创新科技日上，蔚来创始人、董事长、CEO李斌发表演讲。会上，蔚来手机NIOPhone正式亮相。对于为什么要做手机，李斌表示，不是因为手机公司都在造车，也不是因为蔚来造车不赚钱要用手机盈利，而是蔚来用户需要一款...</p>\n\n<a href=\"https://finance.sina.com.cn/tech/2023-09-21/doc-imznmtch2057803.shtml\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"https://static.tigerbbs.com/f7bf4de57d1b73465b979eec75a271ad","relate_stocks":{"NIO":"蔚来","09866":"蔚来-SW"},"source_url":"https://finance.sina.com.cn/tech/2023-09-21/doc-imznmtch2057803.shtml","is_english":false,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1196669385","content_text":"蔚来发布旗舰手机NIO Phone，分为“性能版”、“旗舰版”、“EPedition”三个版本，售价分别为6499元、6899元、7499元。9月21日上午，在今日的NIO IN 2023蔚来创新科技日上，蔚来创始人、董事长、CEO李斌发表演讲。会上，蔚来手机NIOPhone正式亮相。对于为什么要做手机，李斌表示，不是因为手机公司都在造车，也不是因为蔚来造车不赚钱要用手机盈利，而是蔚来用户需要一款与蔚来汽车无缝连接的手机。他表示，蔚来手机NIOPhone定位是一部旗舰手机，搭载高通骁龙8Gen2领先版，最高16GB+1T内存组合可选。配备6.81英寸屏幕，支持1-120Hz可变刷新率，搭载5000万广角+超广角+潜望长焦后置三摄。蔚来NIO Phone发布，起售价6499元，将于9月28日开始交付蔚来发布旗舰手机NIO Phone，分为“性能版”、“旗舰版”、“EPedition”三个版本，售价分别为6499元、6899元、7499元，将于9月28日开始交付。硬件方面，该款手机将搭载高通骁龙8 Gen2处理器，配备6.81英寸屏幕支持120Hz高刷，搭载后置三摄，最高可选 16GB + 1TB 存储；软件方面，搭载基于安卓系统的SKY UI，并且零广告、零预装App，支持30项功能通过“车控键”一键直达。","news_type":1,"symbols_score_info":{"NIO":1.1,"09866":1.1}},"isVote":1,"tweetType":1,"viewCount":3166,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":202477806293232,"gmtCreate":1690471510129,"gmtModify":1690471511165,"author":{"id":"3525666228690124","authorId":"3525666228690124","name":"中原狙神","avatar":"https://static.laohu8.com/default-avatar.jpg","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3525666228690124","idStr":"3525666228690124"},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/CCL\">$嘉年华邮轮(CCL)$&nbsp;</a>皇家新高了，你还在底部墨迹","listText":"<a href=\"https://laohu8.com/S/CCL\">$嘉年华邮轮(CCL)$&nbsp;</a>皇家新高了，你还在底部墨迹","text":"$嘉年华邮轮(CCL)$ 皇家新高了，你还在底部墨迹","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":1,"commentSize":1,"repostSize":0,"link":"https://laohu8.com/post/202477806293232","isVote":1,"tweetType":1,"viewCount":7580,"authorTweetTopStatus":1,"verified":2,"comments":[{"author":{"id":"3547635175516686","authorId":"3547635175516686","name":"纯冰糖","avatar":"https://static.tigerbbs.com/74b08b420511b7c477a80b97c93e17b9","crmLevel":1,"crmLevelSwitch":0,"authorIdStr":"3547635175516686","idStr":"3547635175516686"},"content":"皇家马上恢复到疫情之前了","text":"皇家马上恢复到疫情之前了","html":"皇家马上恢复到疫情之前了"}],"imageCount":0,"langContent":"CN","totalScore":0},{"id":658884116,"gmtCreate":1682524011835,"gmtModify":1682524012987,"author":{"id":"3525666228690124","authorId":"3525666228690124","name":"中原狙神","avatar":"https://static.laohu8.com/default-avatar.jpg","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3525666228690124","idStr":"3525666228690124"},"themes":[],"htmlText":"<a 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邮轮退出历史舞台了吗[无语]","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":1,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/623858779","isVote":1,"tweetType":1,"viewCount":38330,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":629881536,"gmtCreate":1670407048125,"gmtModify":1670407265764,"author":{"id":"3525666228690124","authorId":"3525666228690124","name":"中原狙神","avatar":"https://static.laohu8.com/default-avatar.jpg","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3525666228690124","idStr":"3525666228690124"},"themes":[],"htmlText":"全靠吹","listText":"全靠吹","text":"全靠吹","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/629881536","repostId":"1141647505","repostType":2,"repost":{"id":"1141647505","kind":"news","pubTimestamp":1670403909,"share":"https://www.laohu8.com/m/news/1141647505?lang=zh_CN&edition=full","pubTime":"2022-12-07 17:05","market":"sh","language":"zh","title":"《Nature》：大发现！终结新冠的药找到了？","url":"https://stock-news.laohu8.com/highlight/detail?id=1141647505","media":"医诺维","summary":"一种治疗肝病的药物熊去氧胆酸（UDCA）可以关闭 ACE2 受体。","content":"<html><head></head><body><p><b>新冠病毒</b>，通常通过呼吸道感染人类，并造成呼吸系统和人体各个器官的损伤。自2019年底首次爆发至今，新型冠状病毒仍在全球肆虐，对世界经济、社会造成极大的负面影响。</p><p>随着新冠病毒的大规模流行，新的病毒突变株不断出现，Alpha、Beta、Gamma、Delta、Omicron等，其中一些突变株具有更强的感染能力或更强免疫逃逸能力，目前全世界最关注的当属 <b>Omicron</b> 突变株。</p><p>先前的研究表明，新冠病毒主要通过其表面刺突蛋白与人体细胞上的血管紧张素转化酶2（ACE2）受体结合实现感染，刺突蛋白是新冠病毒识别宿主细胞的蛋白，也是人体免疫系统的主要攻击目标，ACE2 是新冠病毒的主要进入受体。</p><p>如果将 ACE2 受体关闭，那是不是可以预防所有的变体？</p><p>2022年12月5日，英国剑桥大学的研究人员在《Nature》期刊发表了一篇题为&#34; FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2 &#34;的研究论文。</p><p>该研究显示，<b>一种治疗肝病的药物熊去氧胆酸（UDCA）可以关闭 ACE2 受体，关闭了病毒进入细胞的大门，该药物可以用于预防新冠感染，由于这种药物针对的是宿主细胞而不是病毒，因此它可能预防病毒的未来新变种，以及可能出现的其他冠状病毒。</b></p><p><img src=\"https://static.tigerbbs.com/332e4befc4c3a42fa84e9f79c69de4c7\" tg-width=\"640\" tg-height=\"291\" referrerpolicy=\"no-referrer\"/></p><p>众所周知，疫苗是通过增强免疫系统来保护我们，使其能够识别并攻击病毒。但疫苗并不适用于所有人，例如免疫系统较弱的患者。此外，病毒还能通过变异，来逃避疫苗产生的抗体。所以，找到替代方法来保护我们免于新冠感染变得尤为重要。</p><p>从类型器官和动物开始</p><p>此前，该研究作者一直在使用类器官研究胆管疾病。在类器官研究中，研究人员偶然发现一种名为 FXR 的分子大量存在于这些胆管类器官中，重要的是，<b>FXR 可以直接调节 ACE2 受体的打开和关闭状态。</b></p><p>研究人员还发现，<b>一种用于治疗原发性胆汁性胆管炎的肝病的非专利药物，熊去氧胆酸（UDCA），可以降低FXR并关闭ACE2通道。</b></p><p><img src=\"https://static.tigerbbs.com/31a1eb33e3a6fd2dc6e05919fc4749df\" tg-width=\"640\" tg-height=\"349\" referrerpolicy=\"no-referrer\"/></p><p>在该研究中，研究人员通过相同的方法，关闭了肺类器官和肠类器官中的 ACE2 通道，而肺和肠道是新冠病毒的两个主要靶标，可以防止病毒感染。</p><p>进一步，研究人员验证了药物不仅可以预防实验室培养细胞的感染，还可以预防活生物体的感染。</p><p>在感染新冠病毒 Delta 变体的仓鼠模型中，<b>研究发现，用 UDCA 药物治疗的仓鼠受到了保护，免受 Delta 变种的侵害。</b></p><p>研究人员表示，尽管还需要对照的随机试验来证实这些发现，但数据提供了令人信服的证据，表明 UDCA 可以用来预防新冠。</p><p>对人体器官分析</p><p>接下来，研究人员分析了人类肺部，进一步验证在仓鼠身上的发现是否适用于暴露于新冠的人类肺部。</p><p><img src=\"https://static.tigerbbs.com/6a257d6d2c6c522edc459c88683a311d\" tg-width=\"640\" tg-height=\"181\" referrerpolicy=\"no-referrer\"/></p><p>人类肺部分析</p><p>研究人员用呼吸机让2个捐赠肺在体外呼吸，并用泵让类似血液的液体在肺中循环，以保持器官的功能，两个肺都暴露于病毒，其中一个被给予 UDCA 药物。<b>结果显示，接受药物的肺没有被感染，而另一个肺却感染了。</b></p><p>从器官到人类</p><p>最后，研究人员招募了8名志愿者，来测试 UDCA 药物，通过擦拭鼻子，发现ACE2水平较低，这表明病毒侵入并感染他们的鼻细胞的机会更低。</p><p>尽管不可能进行全面的临床试验，研究人员分析了两个独立患者队列的新冠感染数据，比较了那些已经服用 UDCA 治疗肝脏疾病的患者与未服用该药物的患者，<b>发现接受UDCA的患者发生严重新冠肺炎并住院的可能性较小。</b></p><p>总结</p><p>研究人员表示，得来全不费工夫，发现一种现有的药物可以关闭新冠病毒进入细胞的大门，保护我们免受新冠病毒的侵袭。重要的是，由于这种药物作用于我们的细胞，它不受病毒突变的影响，即使出现新的变异也应该有效。</p><p>此外，UDCA已经在临床上使用了很多年，所以我们知道它是安全的并且耐受性很好，并且这种药片成本低廉，可以快速大量生产且易于储存或运输。</p><p>研究人员强调，我们乐观地认为这种药物可能成为我们对抗新冠的重要武器。</p></body></html>","source":"lsy1670403939567","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>《Nature》：大发现！终结新冠的药找到了？</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\n《Nature》：大发现！终结新冠的药找到了？\n</h2>\n\n<h4 class=\"meta\">\n\n\n2022-12-07 17:05 北京时间&nbsp;&nbsp;&nbsp;<a href=https://mp.weixin.qq.com/s/6TSv7DxGBQ_Uo36aAVTm0g><strong>医诺维</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>新冠病毒，通常通过呼吸道感染人类，并造成呼吸系统和人体各个器官的损伤。自2019年底首次爆发至今，新型冠状病毒仍在全球肆虐，对世界经济、社会造成极大的负面影响。随着新冠病毒的大规模流行，新的病毒突变株不断出现，Alpha、Beta、Gamma、Delta、Omicron等，其中一些突变株具有更强的感染能力或更强免疫逃逸能力，目前全世界最关注的当属 Omicron 突变株。先前的研究表明，新冠病毒...</p>\n\n<a href=\"https://mp.weixin.qq.com/s/6TSv7DxGBQ_Uo36aAVTm0g\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"https://static.tigerbbs.com/424a61980d8d04f8172cdf5eafb309c0","relate_stocks":{"BK4568":"美国抗疫概念","BK1515":"抗疫概念"},"source_url":"https://mp.weixin.qq.com/s/6TSv7DxGBQ_Uo36aAVTm0g","is_english":false,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1141647505","content_text":"新冠病毒，通常通过呼吸道感染人类，并造成呼吸系统和人体各个器官的损伤。自2019年底首次爆发至今，新型冠状病毒仍在全球肆虐，对世界经济、社会造成极大的负面影响。随着新冠病毒的大规模流行，新的病毒突变株不断出现，Alpha、Beta、Gamma、Delta、Omicron等，其中一些突变株具有更强的感染能力或更强免疫逃逸能力，目前全世界最关注的当属 Omicron 突变株。先前的研究表明，新冠病毒主要通过其表面刺突蛋白与人体细胞上的血管紧张素转化酶2（ACE2）受体结合实现感染，刺突蛋白是新冠病毒识别宿主细胞的蛋白，也是人体免疫系统的主要攻击目标，ACE2 是新冠病毒的主要进入受体。如果将 ACE2 受体关闭，那是不是可以预防所有的变体？2022年12月5日，英国剑桥大学的研究人员在《Nature》期刊发表了一篇题为\" FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2 \"的研究论文。该研究显示，一种治疗肝病的药物熊去氧胆酸（UDCA）可以关闭 ACE2 受体，关闭了病毒进入细胞的大门，该药物可以用于预防新冠感染，由于这种药物针对的是宿主细胞而不是病毒，因此它可能预防病毒的未来新变种，以及可能出现的其他冠状病毒。众所周知，疫苗是通过增强免疫系统来保护我们，使其能够识别并攻击病毒。但疫苗并不适用于所有人，例如免疫系统较弱的患者。此外，病毒还能通过变异，来逃避疫苗产生的抗体。所以，找到替代方法来保护我们免于新冠感染变得尤为重要。从类型器官和动物开始此前，该研究作者一直在使用类器官研究胆管疾病。在类器官研究中，研究人员偶然发现一种名为 FXR 的分子大量存在于这些胆管类器官中，重要的是，FXR 可以直接调节 ACE2 受体的打开和关闭状态。研究人员还发现，一种用于治疗原发性胆汁性胆管炎的肝病的非专利药物，熊去氧胆酸（UDCA），可以降低FXR并关闭ACE2通道。在该研究中，研究人员通过相同的方法，关闭了肺类器官和肠类器官中的 ACE2 通道，而肺和肠道是新冠病毒的两个主要靶标，可以防止病毒感染。进一步，研究人员验证了药物不仅可以预防实验室培养细胞的感染，还可以预防活生物体的感染。在感染新冠病毒 Delta 变体的仓鼠模型中，研究发现，用 UDCA 药物治疗的仓鼠受到了保护，免受 Delta 变种的侵害。研究人员表示，尽管还需要对照的随机试验来证实这些发现，但数据提供了令人信服的证据，表明 UDCA 可以用来预防新冠。对人体器官分析接下来，研究人员分析了人类肺部，进一步验证在仓鼠身上的发现是否适用于暴露于新冠的人类肺部。人类肺部分析研究人员用呼吸机让2个捐赠肺在体外呼吸，并用泵让类似血液的液体在肺中循环，以保持器官的功能，两个肺都暴露于病毒，其中一个被给予 UDCA 药物。结果显示，接受药物的肺没有被感染，而另一个肺却感染了。从器官到人类最后，研究人员招募了8名志愿者，来测试 UDCA 药物，通过擦拭鼻子，发现ACE2水平较低，这表明病毒侵入并感染他们的鼻细胞的机会更低。尽管不可能进行全面的临床试验，研究人员分析了两个独立患者队列的新冠感染数据，比较了那些已经服用 UDCA 治疗肝脏疾病的患者与未服用该药物的患者，发现接受UDCA的患者发生严重新冠肺炎并住院的可能性较小。总结研究人员表示，得来全不费工夫，发现一种现有的药物可以关闭新冠病毒进入细胞的大门，保护我们免受新冠病毒的侵袭。重要的是，由于这种药物作用于我们的细胞，它不受病毒突变的影响，即使出现新的变异也应该有效。此外，UDCA已经在临床上使用了很多年，所以我们知道它是安全的并且耐受性很好，并且这种药片成本低廉，可以快速大量生产且易于储存或运输。研究人员强调，我们乐观地认为这种药物可能成为我们对抗新冠的重要武器。","news_type":1,"symbols_score_info":{}},"isVote":1,"tweetType":1,"viewCount":2736,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0}],"hots":[{"id":952971441,"gmtCreate":1591863354683,"gmtModify":1704197292993,"author":{"id":"3525666228690124","authorId":"3525666228690124","name":"中原狙神","avatar":"https://static.laohu8.com/default-avatar.jpg","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3525666228690124","idStr":"3525666228690124"},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/M\">$梅西百货(M)$</a>每天跌10个点，这他妈谁扛的住[喷血]&nbsp;","listText":"<a 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