Biostage, Inc., a biotechnology company, engages in developing bioengineered organ implants based on its Cellframe technology. The company's Cellframe technology combines the synthetic scaffold with tissue engineering and cell biology to create method of addressing organ damage. Its Cellframe technology stimulates the body's signaling pathways and natural healing process to regenerate and restore organ function. The company is developing organ implants as a platform of being used in the esophagus, trachea, and bronchi. Its implants are being advanced and tested in preclinical collaborative studies with Mayo Clinic and Connecticut Children's Medical Center. The company was formerly known as Harvard Apparatus Regenerative Technology, Inc. and changed its name to Biostage, Inc. in March 2016. Biostage, Inc. was founded in 2012 and is headquartered in Holliston, Massachusetts.