翰森制药(03692.HK)：HS-10374治疗中重度斑块状银屑病III期临床研究达到共同主要终点

智通财经09-21 08:36

【翰森制药(03692.HK)：HS-10374治疗中重度斑块状银屑病III期临床研究达到共同主要终点】智通财经APP讯，翰森制药(03692.HK)发布公告，集团自研酪氨酸激酶2(TYK2)选择性变构抑制剂 HS-10374，在用于成人中重度斑块状银屑病的关键性III期临床试验中达到共同主要终点：在治疗的第16周，HS-10374组达到银屑病面积和严重程度指数(PASI)相较于基线下降至少75% (PASI 75)的患者比例，以及达到静态医师整体评估(sPGA)评分0或1且较基线期降低至少2分(sPGA 0/1)的患者比例，均显著高于安慰剂组。试验亦达到多项次要终点：在第16周，接受HS-10374治疗的患者中超过一半达到PASI 90应答，近1/3达到PASI 100应答。同时，HS-10374显示了良好的安全性和耐受性，其安全性特征与同类TYK2抑制剂类似，未观察到新的安全性信号。

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