挑战PD-L1“药王”成功，康方生物的PD-1双抗擂台赛从肺癌打到了胆道癌

第一财经08-26 09:33

继头对头挑战默沙东K药物后，康方生物（09926.HK)的PD-1/VEGF双抗依沃西擂台赛还在继续。　　8月26日，康方生物宣布，依沃西联合化疗方案，对比度伐利尤单抗联合化疗方案，用于一线治疗晚期胆道恶性肿瘤(BTC)的随机、双盲、对照、多中心、注册性III期临床研究(AK112-309/HARMONi-GI1)，经独立数据监察委员会(IDMC)评估的预先设定的期中分析显示：研究达到总生存期(...

网页链接

免责声明：本文观点仅代表作者个人观点，不构成本平台的投资建议，本平台不对文章信息准确性、完整性和及时性做出任何保证，亦不对因使用或信赖文章信息引发的任何损失承担责任。

精彩评论

我们需要你的真知灼见来填补这片空白

发表看法

{"i18n":{"language":"zh_CN"},"isChannel":false,"data":{"share":"https://www.laohunote.com/m/news/2662192769?lang=zh_CN&edition=full","thumbnail":"","is_english":false,"pubTime":"2026-08-26 09:33","share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","id":"2662192769","market":"us","top_or_hot":-1,"title":"挑战PD-L1“药王”成功，康方生物的PD-1双抗擂台赛从肺癌打到了胆道癌","media":"第一财经","content":"<div>\n<p>继头对头挑战默沙东K药物后，康方生物（09926.HK)的PD-1/VEGF双抗依沃西擂台赛还在继续。　　8月26日，康方生物宣布，依沃西联合化疗方案，对比度伐利尤单抗联合化疗方案，用于一线治疗晚期胆道恶性肿瘤(BTC)的随机、双盲、对照、多中心、注册性III期临床研究(AK112-309/HARMONi-GI1)，经独立数据监察委员会(IDMC)评估的预先设定的期中分析显示：研究达到总生存期(...</p>\n\n<a href=\"http://finance.eastmoney.com/a/202608263854239539.html\">网页链接</a>\n\n</div>\n","source":"stock_eastmoney","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>挑战PD-L1“药王”成功，康方生物的PD-1双抗擂台赛从肺癌打到了胆道癌</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\n挑战PD-L1“药王”成功，康方生物的PD-1双抗擂台赛从肺癌打到了胆道癌\n</h2>\n\n<h4 class=\"meta\">\n\n\n2026-08-26 09:33 北京时间&nbsp;&nbsp;&nbsp;<a href=http://finance.eastmoney.com/a/202608263854239539.html><strong>第一财经</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>继头对头挑战默沙东K药物后，康方生物（09926.HK)的PD-1/VEGF双抗依沃西擂台赛还在继续。　　8月26日，康方生物宣布，依沃西联合化疗方案，对比度伐利尤单抗联合化疗方案，用于一线治疗晚期胆道恶性肿瘤(BTC)的随机、双盲、对照、多中心、注册性III期临床研究(AK112-309/HARMONi-GI1)，经独立数据监察委员会(IDMC)评估的预先设定的期中分析显示：研究达到总生存期(...</p>\n\n<a href=\"http://finance.eastmoney.com/a/202608263854239539.html\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"09926","symbol_name":"康方生物","start_time":0,"source_url":"http://finance.eastmoney.com/a/202608263854239539.html","article_id":"2662192769","we_media_id":null,"thumbnails":[],"rights":{"source":"stock_eastmoney","url":"http://finance.eastmoney.com/a/202608263854239539.html","rn_cache_url":null,"directOrigin":true},"url":"https://stock-news.laohu8.com/highlight/detail?id=2662192769","pubTimestamp":1787708009,"columns":[],"sourceInfo":{"source_id":"stock_eastmoney","name":"东方财富"},"weMediaInfo":null,"summary":"继头对头挑战默沙东K药物后，康方生物（09926.HK)的PD-1/VEGF双抗依沃西擂台赛还在继续。","collect":0,"end_time":0,"defaultTopTitle":"eastmoney.com","property":[],"viewcount":null,"language":"zh","relate_stocks":{"09926":"康方生物","KURE":"KraneShares MSCI All China Health Care Index ETF","BK1574":"生物医药B类股","LU0540923850.HKD":"ALLIANZ HONG KONG EQUITY \"A\" (HKD) INC","LU1720050803.USD":"安联全方位中国股票基金","IE00B543WZ88.USD":"NEUBERGER BERMAN CHINA EQUITY \"A\" (USD) ACC","LU0634319403.HKD":"ALLIANZ HONG KONG EQUITY \"AT\" (HKD) ACC","LU1961090484.USD":"ALLIANZ ALL CHINA EQUITY \"A\" (USD) INC","LU1169589451.USD":"ALLSPRING (LUX)  U.S. SELECT EQUITY \"A\" (USD) ACC","LU0417516902.SGD":"Allianz China Equity Cl AT Acc SGD","LU2488822045.USD":"ALLIANZ CHINA HEALTHY LIVING \"AT\" (USD) ACC","LU2476274308.USD":"ALLIANZ CHINA FUTURE TECHNOLOGIES \"AT\" (USD) ACC","LU0348783233.USD":"安联东方收入型 CI A Dis美元","LU0348825331.USD":"ALLIANZ CHINA EQUITY \"A\" (USD) INC","LU0348784397.USD":"ALLIANZ ORIENTAL INCOME \"A\" (USD) ACC","LU1794554557.SGD":"Allianz All China Equity AT Acc H2-SGD","PD":"PagerDuty, Inc.","LU2778985437.USD":"ALLIANZ CHINA FUTURE TECHNOLOGIES \"A\" (USD) INC","IE00B5MMRT66.SGD":"NEUBERGER BERMAN CHINA EQUITY \"A\" (SGDHDG) ACC","LU0561508036.HKD":"ALLIANZ CHINA EQUITY \"A\" (HKD) INC","LU2476274720.SGD":"ALLIANZ CHINA FUTURE TECHNOLOGIES \"AT\" (SGDHDG) ACC","LU0348766576.USD":"ALLIANZ LITTLE DRAGONS \"A\" (USD) INC","LU1169590202.USD":"ALLSPRING (LUX)  U.S. SELECT EQUITY \"I\" (USD) ACC","LU0348767384.USD":"ALLIANZLITTLE DRAGONS \"A\" (USD) ACC","BK1161":"生物科技","LU2399975544.HKD":"ALLIANZ ALL CHINA EQUITY \"AT\" (HKD) ACC","LU0417516571.SGD":"Allianz Oriental Income Cl AT Acc SGD","BK4023":"应用软件","IE00BPRC5H50.USD":"NEUBERGER BERMAN CHINA EQUITY \"A\" (USD) INC","LU0348827113.USD":"ALLIANZ RCM CHINA \"AT\" ACC","LU0417516738.SGD":"Allianz Hong Kong Equity AT Acc SGD","LU0348735423.USD":"ALLIANZ HONG KONG EQUITY \"A\" (USD) INC"},"translate_title":"Challenging PD-L1 \"Drug King\" successfully, Kangfang Biological's PD-1 double antibody competition went from lung cancer to biliary tract cancer","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"KURE":0.6,"PD":1.5,"09926":1.5},"content_text":"继头对头挑战默沙东K药物后，康方生物（09926.HK)的PD-1/VEGF双抗依沃西擂台赛还在继续。　　8月26日，康方生物宣布，依沃西联合化疗方案，对比度伐利尤单抗联合化疗方案，用于一线治疗晚期胆道恶性肿瘤(BTC)的随机、双盲、对照、多中心、注册性III期临床研究(AK112-309/HARMONi-GI1)，经独立数据监察委员会(IDMC)评估的预先设定的期中分析显示：研究达到总生存期(OS)主要研究终点，取得具有统计学显著性和重大临床获益的阳性结果；研究也达到无进展生存期(PFS)与客观缓解率(ORR)的所有关键次要终点。　　这是在中国开展的临床试验。这意味着，在该研究上，依沃西挑战度伐利尤单抗的疗效已取得初步胜出结果。　　度伐利尤单抗是阿斯利康旗下开发的PD-L1单抗。在胆道癌领域，度伐利尤单抗联合化疗也是目前国内外指南共同推荐的一线免疫最优治疗方案。　　在全球PD-L1药物竞争格局中，阿斯利康的度伐利尤单抗销售额位列第一。2025年，度伐利尤单抗全球销售额为60.63亿美元，同比增长28.54%。　　HARMONi-GI1研究是首个在胆道癌领域以全球最优金标准（PD-L1单抗联合化疗）为对照，取得OS显著阳性结果的III期研究。　　此次HARMONi-GI1研究结果公布之前，依沃西已在肺癌领域斩获多项III期阳性结果。在肺癌领域，依沃西最轰动全球资本市场的一仗是，成为全球首个在头对头III期临床中击败默沙东帕博利珠单抗（即K药物，全球销售额最高的PD-1单抗），由此吸引各大药企们竞相押注PD-1/VEGF双抗赛道。　　康方生物创始人、董事长、总裁兼首席执行官夏瑜表示，HARMONi-GI1研究取得阳性结果，是依沃西继在肺癌领域斩获多项III期阳性结果之后，首个在消化道肿瘤领域获得阳性结果的III期研究，依沃西的突破性临床价值正在由肺癌向更广泛的实体瘤领域拓展。　　作为肿瘤免疫的核心靶点，PD-（L）1因其广谱抗肿瘤作用及持久抗肿瘤作用奠定了在免疫治疗领域的基石地位，但由于免疫微环境的复杂性及耐药性，整个PD-（L）1仍无法完全满足临床需求，众多药企正在比拼开发新一代免疫基石疗法。　　值得一提的是，作为全球首款研发上市的PD-1/VEGF双抗，依沃西已率先在中国获批上市，用于治疗肺癌，与此同时，依沃西正在美国申请上市中，而这场上市也将决定PD-1/VEGF双抗能否真正改变PD-（L）1免疫药王之位。（文章来源：第一财经）","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":false,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":1,"need_auth":false,"need_login_tip":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"isLaohu8Offline":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.44.1","shortVersion":"4.44.1","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2662192769","isCrawlerRequest":true}