默沙东卡位ADC+IO2.0! 科伦博泰TROP2 ADC联合PD-1/VEGF双抗的II期临床启动

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炒股就看金麒麟分析师研报，权威，专业，及时，全面，助您挖掘潜力主题机会！　　来源：医药魔方Info 　　近期，默沙东官网新增TROP2 ADC芦康沙妥珠单抗（sac-TMT，佳泰莱®）联合PD-1/VEGF双抗MK-2010治疗晚期实体瘤患者的一项开放标签II期临床研究MK-2010-003。目前该研究处于启动（start-up）阶段，研究中心为瑞士“St． Gallen， Bellinzona...

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Phase II clinical initiation of Kelunbotai TROP2 ADC combined with PD-1/VEGF dual antibody","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"VHT":0.6,"06990":1.95,"FTXH":0.6,"BMED":0.6,"PPH":0.6,"IXJ":0.6,"IYH":0.6,"MRK":1.97,"PAWZ":0.6,"JDOC":0.6,"XLV":0.6,"RXL":0.6,"IHE":0.6,"GDOC":0.6,"TRUH":0.6,"FHLC":0.6,"HRTS":0.6},"content_text":"炒股就看金麒麟分析师研报，权威，专业，及时，全面，助您挖掘潜力主题机会！ 　　来源：医药魔方Info\n　　近期，默沙东官网新增TROP2 ADC芦康沙妥珠单抗（sac-TMT，佳泰莱®）联合PD-1/VEGF双抗MK-2010治疗晚期实体瘤患者的一项开放标签II期临床研究MK-2010-003。目前该研究处于启动（start-up）阶段，研究中心为瑞士“St． Gallen， Bellinzona”。\n\n　　芦康沙妥珠单抗（sac-TMT）是科伦博泰拥有自主知识产权的新型TROP2 ADC，针对非小细胞肺癌（NSCLC）、乳腺癌（BC）、胃癌（GC）、妇科肿瘤及泌尿生殖系统肿瘤等晚期实体瘤。\n　　芦康沙妥珠单抗（sac-TMT）采用独特双功能连接子开发而成，一方面通过与抗TROP2单抗沙妥珠单抗形成不可逆结合，另一方面连接子可pH敏感裂解，最大限度将有效载荷递送至肿瘤细胞，药物抗体比（DAR）达到7.4。该药物特异性识别肿瘤细胞表面的TROP2，其后被肿瘤细胞内吞并于细胞内释放有效载荷KL610023。KL610023作为拓扑异构酶I抑制剂，可诱导肿瘤细胞DNA损伤，进而导致细胞周期阻滞及细胞凋亡。此外，其亦于肿瘤微环境中释放KL610023。鉴于KL610023具有细胞膜渗透性，其可实现旁观者效应，即杀死邻近的肿瘤细胞。\n　　2022年5月，科伦博泰已授予默沙东在大中华区（包括中国内地、香港、澳门及台湾）以外的所有地区开发、使用、制造及商业化芦康沙妥珠单抗（sac-TMT）的独家权利。\n　　目前，默沙东针对核心产品芦康沙妥珠单抗（sac-TMT）布局的全球性III期临床研究已达17项，这一研究数量也位居默沙东ADC管线首位，体现了其对中国创新药的高度认可与深度绑定。值得一提的是，其中一项用于治疗特定晚期或复发性子宫内膜癌的全球III期TroFuse-005临床研究已于今年5月达到总生存期（OS）和无进展生存期（PFS）的双主要终点，为这一药物的临床价值再添坚实证据。\n　　而此次默沙东新开的MK-2010-003研究以芦康沙妥珠单抗（sac-TMT）和PD-1/VEGF双抗MK-2010为试验药物，探索该联用组合在实体瘤患者的疗效与安全性。两者的强强联合，体现了默沙东对芦康沙妥珠单抗和MK-2010治疗潜力的深度看好，这种“ADC+IO2.0”的组合模式极有可能引领肿瘤治疗的新一轮迭代。\n　　从更深层看，芦康沙妥珠单抗（sac-TMT）和MK-2010的联用具备科学的协同逻辑。此前，芦康沙妥珠单抗已通过与帕博利珠单抗等PD-（L）1抑制剂的联合研究（如OptiTROP-Lung05）取得积极数据，已经验证了“ADC+IO”模式的可行性；而PD-1/VEGF双抗在PD-（L）1抑制剂的基础上增加了抗血管生成作用，与ADC联用可通过调节血管生成与血管孔隙度改变肿瘤血管系统，以促进ADC渗透并暴露于肿瘤细胞，增强ADC的抗肿瘤活性。\n　　默沙东此次快速卡位“ADC+IO2.0”双抗联合赛道，不仅是其全球研发战略的关键落子，也标志着中国本土创新ADC药物正加速融入国际主流治疗体系。芦康沙妥珠单抗（sac-TMT）作为科伦博泰的拳头产品，已“借船出海”进阶为默沙东管线中的核心资产。随着更多全球临床数据的读出，这一源自中国的创新分子，或将为全球晚期实体瘤患者带来更具突破性的治疗选择，同时也为中国创新药全球化写下又一注脚。\n　　Copyright © 2026 PHARMCUBE． All Rights Reserved． 免责申明：本微信文章中的信息仅供一般参考之用，不可直接作为决策内容，医药魔方不对任何主体因使用本文内容而导致的任何损失承担责任。\n新浪声明：此消息系转载自新浪合作媒体，新浪网登载此文出于传递更多信息之目的，并不意味着赞同其观点或证实其描述。文章内容仅供参考，不构成投资建议。投资者据此操作，风险自担。","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":false,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":1,"need_auth":false,"need_login_tip":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"isLaohu8Offline":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.44.1","shortVersion":"4.44.1","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2655189942","isCrawlerRequest":true}