石药创新(300765.SZ)控股子公司SYS6043启动Ⅲ期临床试验

智通财经07-16 16:59

智通财经APP讯，石药创新(300765.SZ)发布公告，公司控股子公司石药集团巨石生物制药有限公司(简称“巨石生物”)已于近日启动一项评价SYS6043对比研究者选择的化疗用于铂耐药晚期卵巢癌、原发性腹膜癌以及输卵管癌参与者的随机、多中心、开放标签的Ⅲ期临床试验。

据悉，SYS6043(B7-H3 ADC)为巨石生物研制的靶向B7-H3的ADC产品，其抗体部分可特异性结合表达B7-H3的细胞表面并内化入细胞;连接子-药物(Linker-Drug)为四肽连接子偶联拓扑异构酶Ⅰ抑制剂，经蛋白酶特异性剪切可释放小分子毒素杀伤肿瘤细胞，并发挥旁观者效应非特异性杀伤周围肿瘤组织细胞。与传统野生型可结芯片段(Fc)不同，SYS6043可减少淋巴细胞摄取，降低脱靶毒性风险，从而提高治疗安全性。

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