中国创新药迎高光！康方生物核心产品战胜PD-1联合化疗总生存期结果

每日经济新闻05-31

5月31日，《每日经济新闻》记者注意到，在2026年美国临床肿瘤学会（ASCO）年会上，康方生物（HK09926，股价118.10港元，市值1088亿港元）PD-1/VEGF双抗依沃西联合化疗对比替雷利珠单抗联合化疗，一线治疗晚期鳞状非小细胞肺癌（sq-NSCLC）III期HARMONi-6/AK112-306研究的OS（总生存期）显著阳性结果揭晓。　　HARMONi-6研究共入组532例受试者，...

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Overall Survival Results of Kangfang Biological's Core Products Beat PD-1 Combined with Chemotherapy","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"159992":1.5,"09926":1.5,"06978":1.5,"PD":1.5},"content_text":"5月31日，《每日经济新闻》记者注意到，在2026年美国临床肿瘤学会（ASCO）年会上，康方生物（HK09926，股价118.10港元，市值1088亿港元）PD-1/VEGF双抗依沃西联合化疗对比替雷利珠单抗联合化疗，一线治疗晚期鳞状非小细胞肺癌（sq-NSCLC）III期HARMONi-6/AK112-306研究的OS（总生存期）显著阳性结果揭晓。　　HARMONi-6研究共入组532例受试者，中央型鳞癌占比约为63%，PD-L1 TPS<1%占比为39.0%，肿瘤多部位转移/肝转移/脑转移患者占比约33.8%。　　研究结果显示，相比替雷利珠单抗联合化疗，依沃西联合化疗可显著延长患者OS。截至2026年2月27日，中位随访时间为21.36个月时：在ITT人群中，相比替雷利珠单抗联合化疗，依沃西联合化疗可显著降低患者死亡风险达34%，风险比（HR）=0.66（95% CI：0.50—0.87），P=0.0017（<0.0049），治疗组mos为27.9个月（治疗组的最后一例死亡事件导致km曲线急剧下降至中位点，从而产生治疗组mos），对照组mos为23.7个月。<>　　HARMONi-6研究的主要研究者，上海市胸科医院肺部肿瘤临床医学中心主任、终身教授陆舜教授表示，HARMONi-6研究是全球首个在肺癌领域对比PD-1联合化疗取得OS和PFS双显著阳性结果的III期研究，也是全球首个在sq-NSCLC领域通过统计假设验证取得OS和PFS双显著阳性结果的III期临床研究，显著降低了患者死亡风险和疾病进展风险，所有亚组均获益显著，还可以让患者能更长时间地保持更好的总体健康状况和生活质量，也填补了抗血管生成机制药物在sq-NSCLC中不可用的巨大临床空白。　　陆舜还表示，依沃西这一研究成果，以硬核的III期头对头临床研究数据，重新定义了sq-NSCLC一线治疗的金标准，确立了临床获益的新标杆，这是中国创新推动全球肿瘤治疗水平提升的一个里程碑。（文章来源：每日经济新闻）","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":1,"need_auth":false,"need_login_tip":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.43.1","shortVersion":"4.43.1","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2639136988","isCrawlerRequest":true}