Ionis(IONS)及合作伙伴Biogen共同宣布：diranersen相关研究取得具里程碑意义的成果

金吾财讯05-14

金吾财讯 | Ionis(IONS)及其合作伙伴渤健(Biogen)共同宣布，用于治疗早期阿尔茨海默病(AD)的在研反义寡核苷酸(ASO)疗法diranersen(BIIB080)在II期CELIA研究中取得了具有里程碑意义的顶线结果。该研究首次证明，靶向Tau蛋白的疗法在减少病理蛋白堆积的同时，能显著改善患者的认知功能。基于此次研究中展现的生物标志物与疗效的强关联性，渤健已明确表示，计划将diranersen推进至注册开发阶段(即启动III期临床试验)。此前，美国FDA已于2025年授予该药“快速通道”认定。截至发稿，Ionis盘前走强，最新报81.88美元，上涨5.52%。

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