肺纤维化生物技术公司Avalyn Pharma IPO定价18美元募资3亿，今晚登陆纳斯达克

智通财经04-30

智通财经APP获悉，Avalyn Pharma(AVLN.US)是一家处于二期临床试验阶段的生物技术公司，专注于开发治疗罕见呼吸系统疾病的吸入式药物。该公司通过以每股18美元的价格发行1670万股股票，筹集了3亿美元资金，该定价位于此前每股16至18美元发行区间上限。公司最初计划发行1180万股，定价区间同样为16至18美元，后于4月29日扩大发行规模。按此定价计算，公司完全稀释后市值达8.13...

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Pharma致力于研发针对罕见呼吸系统疾病(特别是肺纤维化)的吸入式抗纤维化疗法。其核心候选药物AP01和AP02分别为吡非尼酮和尼达尼布的吸入制剂，旨在将已获批的抗纤维化药物直接递送至肺部，提升局部药物暴露量并减少全身性副作用。针对特发性肺纤维化(IPF)和进行性肺纤维化(PPF)的AP01已完成ATLAS 1b期临床试验，参与患者正转入持续进行的开放标签扩展研究，该研究同时纳入其他IPF和PPF患者队列。AP02作为尼达尼布的吸入剂型，正开发用于肺纤维化治疗，这将拓展公司在两大主流抗纤维化机制领域的产品线布局。本次 IPO 所得资金将主要用于推进公司核心管线的后期临床研究。其中，主导项目 AP01 正在针对特发性肺纤维化(IPF)和进行性肺纤维化(PPF)进行 2b 期临床试验;另一款针对 IPF 的吸入式制剂 AP02 也已进入 2 期临床阶段。此次扩容募资为这些高耗能的临床研究提供了坚实的资金护城河。此外，公司此前已获得包括诺和诺德母公司 Novo Holdings 在内的顶级生物医药风投机构的支持，IPO 后的资金实力将进一步助推其从研发型企业向商业化阶段跨越。这家总部位于马萨诸塞州波士顿的公司将在纳斯达克上市，股票代码为AVLN。摩根士丹利、杰富瑞、Evercore 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