康方生物三抗登场

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近日，康方生物宣布其全球首创的ILT2/ILT4/CSF1R三特异性抗体新药AK150获NMPA临床试验默示许可，用于治疗晚期恶性实体瘤，这也是康方生物首个进入临床阶段的三抗新药。ILT2、ILT4和CSF1R在多种实体瘤中高表达，当前单、双靶点药物难以打破肿瘤免疫抑制网络，多特异性抗体有望破解难题。AK150可协同靶向三个靶点，多角度解除免疫抑制，临床前动物模型显示其有肿瘤抑制作用。康方生物是...

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