荣昌生物：PSMA/B7H3 ADC申报IND正心Ecosphere

动脉网03-08

2026年3月2日，荣昌生物RC288注射液上市申请获NMPA受理。RC288是荣昌生物自主研发的PSMA/B7H3 ADC，采用TOP1i为payload，通过可裂解linker偶联到抗体，运用定点偶联技术，DAR值为8，临床前期研究显示其抗肿瘤活性优异且安全性良好。在开发纬迪西妥单抗后，荣昌生物建立TOPi ADC技术平台，重点推进CDCP1 ADC、PSMA/B7H3 ADC，前者重点探索结...

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