产业新闻 | 礼来单抗/多肽药物组合达3期临床主要终点；穿越血脑屏障！新锐推进新一代阿尔茨海默病疗法……

药明康德02-19

礼来单抗/多肽药物组合达3期临床主要终点礼来（Eli Lilly and Company）今日宣布，TOGETHER-PsO临床3b期研究取得积极顶线结果。该研究评估了Taltz（ixekizumab）联合Zepbound（tirzepatide）相较Taltz单药治疗，在中重度斑块状银屑病合并肥胖或超重（且伴至少一种体重相关合并症）成人患者中的疗效差异。Taltz是一种单克隆抗体，可选择性结合...

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Cutting-edge advances a new generation of Alzheimer's disease therapies...","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"LLY":1.95,"LLYX":0.6,"NVS":1.88,"LLYZ":0.6,"ELIS":0.6,"ELIL":0.6},"content_text":"礼来单抗/多肽药物组合达3期临床主要终点礼来（Eli Lilly and Company）今日宣布，TOGETHER-PsO临床3b期研究取得积极顶线结果。该研究评估了Taltz（ixekizumab）联合Zepbound（tirzepatide）相较Taltz单药治疗，在中重度斑块状银屑病合并肥胖或超重（且伴至少一种体重相关合并症）成人患者中的疗效差异。Taltz是一种单克隆抗体，可选择性结合白细胞介素17A（IL-17A）并抑制其与IL-17受体的相互作用。Zepbound是一款葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽-1（GLP-1）受体双重激动剂。分析显示，接受Taltz与Zepbound联合治疗的患者中，有27.1%同时实现完全皮损清除（PASI 100）及至少10%的体重下降，而Taltz单药组为5.8%，达到主要终点（p<0.001）。在关键次要终点方面，联合治疗使达到PASI 100的患者比例较单药治疗相对提高40%（40.6% vs. 29.0%，p<0.05），提示针对肥胖或超重进行干预可能进一步减轻银屑病疾病负担。安全性方面，联合用药相关不良事件总体为轻至中度，与两种药物既往已知安全性特征一致。根据新闻稿，Taltz为首个拥有两项临床研究数据支持、可与肠促胰素类减重疗法联合探索综合治疗路径的银屑病生物制品。穿越血脑屏障！新锐推进潜在“best-in-class”阿尔茨海默病疗法Korsana Biosciences今日宣布结束隐匿模式并公开亮相。该公司成立于2024年，最初获得Fairmount与Venrock Healthcare Capital Partners提供的2500万美元种子轮融资。2025年9月，Korsana完成1.5亿美元A轮私募融资，由Wellington Management与TCGX共同领投，J.P. Morgan Life Sciences Private Capital、Janus Henderson Investors、Sanofi Ventures以及Foresite Capital等机构参与。该轮融资主要用于推进潜在“best-in-class”神经退行性疾病疗法的研发，初期重点聚焦阿尔茨海默病治疗领域。公司当前的核心项目为KRSA-028，这是一款用于治疗阿尔茨海默病的下一代靶向β淀粉样蛋白的穿梭抗体（shuttled antibody），由Korsana与Paragon Therapeutics合作发现。该候选药物基于Korsana专有的Therapeutic Targeting（THETA）平台开发，结合经临床验证的转铁蛋白受体（TfR1）与Fc工程设计，旨在提升药物进入脑组织的能力，并克服既往TfR1策略存在的局限。KRSA-028被设计用于增强淀粉样斑块清除、降低淀粉样相关影像学异常（ARIA）及血液学不良事件发生率，同时通过低剂量皮下注射给药方式优化患者用药便利性与依从性。与此同时，Korsana还在推进多项基于THETA平台的创新管线，针对其他尚未披露、存在高度未满足临床需求的神经退行性疾病。诺华达成超17亿美元大环肽合作今日，Unnatural Products（UNP）宣布与诺华（Novartis）达成一项研究合作与许可协议，双方将围绕一项尚未披露的项目开展合作。此次合作将整合UNP以人工智能增强的大环肽分子平台与诺华在全球药物开发及商业化方面的能力，共同开发下一代治疗药物，潜在应用方向包括心血管疾病领域。根据协议，诺华将负责推进候选产品的IND支持性研究，并承担后续临床开发、生产制造以及全球商业化工作。大环肽被认为是一类兼具生物制品高选择性与高效力，同时拥有小分子药物灵活性与类药性质的重要治疗形式，有望拓展以往难以成药靶点的开发空间。UNP的综合发现引擎融合AI引导的分子设计、大规模并行合成以及直接生物学筛选技术，可快速生成具备高效力与高选择性的大环肽分子，并适用于口服及注射等多种给药方式。根据协议，UNP有望获得最高1亿美元的预付款及IND前里程碑付款，以及最高17亿美元的开发、监管和商业化里程碑款项。参考资料：[1] Lilly's Taltz (ixekizumab) and Zepbound (tirzepatide) used together delivered superior efficacy in first-of-its-kind Phase 3b trial for adults with psoriasis and obesity or overweight. Retrieved February 18, 2026 from https://www.prnewswire.com/news-releases/lillys-taltz-ixekizumab-and-zepbound-tirzepatide-used-together-delivered-superior-efficacy-in-first-of-its-kind-phase-3b-trial-for-adults-with-psoriasis-and-obesity-or-overweight-302691124.html[2] Korsana Biosciences Emerges from Stealth with $175 Millon in Funding to Advance Potential Best-in-Class Therapeutics for Neurodegenerative Diseases. Retrieved February 18, 2026 from https://www.businesswire.com/news/home/20260218747210/en/Korsana-Biosciences-Emerges-from-Stealth-with-%24175-Millon-in-Funding-to-Advance-Potential-Best-in-Class-Therapeutics-for-Neurodegenerative-Diseases[3] Unnatural Products Announces Licensing Agreement with Novartis to Develop Macrocyclic Peptide Therapeutics. 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