礼来替尔泊肽国内第5项适应症落地，减肥药全球版图已成型，持续扩张中！

摩熵医药大数据02-13

2月12日，$LLY(LLY)礼来制药宣布，其GLP-1R/GIPR双重激动剂替尔泊肽在国内获批成人2型糖尿病（T2DM）单药治疗新适应症。更新后的说明书同步扩容，覆盖从单药到联合多种降糖药的全场景应用——在饮食控制与运动基础上，均可用于改善成人T2DM患者的血糖控制。截图来源：企业官微这意味着，替尔泊肽在中国糖尿病治疗路径上实现“单药起始→联合强化”的完整闭环，为不同病情阶段患者提供灵活...

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在国内适应症增至5项：•T2DM联合治疗：二甲双胍/磺脲类疗效不佳者；•T2DM单药治疗：本次新增，饮食运动基础上的成人患者；•长期体重管理：BMI≥28（肥胖）或≥24（超重+合并症）；•OSA治疗：成人肥胖患者中重度阻塞性睡眠呼吸暂停；•T2DM联合胰岛素：联合胰岛素±口服降糖药控糖。截图来源：摩熵医药-全球药物研发数据库后替尔泊肽时代：口服药+三靶点接力作为首个市值破万亿美元的药企，礼来聚焦代谢、肿瘤、免疫、神经四大领域，其中代谢是绝对核心。为延续优势，礼来在GLP-1赛道提前布下两枚关键棋子：口服GLP-1R激动剂 Orforglipron（奥氟格列隆）：全球监管申报启动，商业化在即。2025年12月FDA受理NDA，2026年1月国内CDE受理上市申请。GLP-1R/GCGR/GIPR三靶点激动剂 Retatrutide（瑞他鲁肽）：后期临床减重效果高达29%，有望成为下一代“超级减肥针”。随着现有管线适应症不断拓宽、后续管线加速推进，慢病治疗或将迎来颠覆性革新，而药企也将在这场机遇与挑战并存的竞赛中重新洗牌。","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; 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