诺和诺德：GLP-1/GIP/GCG启动减重二期临床

医药笔记02-10

▎Armstrong2026年2月9日，诺和诺德在Clinicaltrials.gov网站上注册了UBT251用于治疗肥胖的全球二期临床试验。该二期临床计划入组333例肥胖或超重受试者，预计2027年1月完成。UBT251为联邦制药自主研发的GLP-1/GIP/GCG受体激动剂。根据2024年披露的一期临床数据，半衰期为136-170小时，支持每周一次给药，1.0-4.5mg剂量范围内，体重下降...

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href=http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN2026021008564095407eb9&s=b><strong>医药笔记</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>▎Armstrong2026年2月9日，诺和诺德在Clinicaltrials.gov网站上注册了UBT251用于治疗肥胖的全球二期临床试验。该二期临床计划入组333例肥胖或超重受试者，预计2027年1月完成。UBT251为联邦制药自主研发的GLP-1/GIP/GCG受体激动剂。根据2024年披露的一期临床数据，半衰期为136-170小时，支持每周一次给药，1.0-4.5mg剂量范围内，体重下降...</p>\n\n<a 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Retatrutide治疗68周减重幅度分别为26.4%、28.7%，安慰剂组减重2.1%。骨关节炎评分指数（WOMAC）也实现显著改善。Armstrong技术全梳理系列GPRC5D靶点全梳理；CD40靶点全梳理；CD47靶点全梳理；补体靶向药物技术全梳理；补体药物：眼科治疗的重要方向；Claudin 6靶点全梳理；Claudin 18.2靶点全梳理；靶点冷暖，行业自知；中国大分子新药研发格局；被炮轰的“me too”；佐剂百年史；胰岛素百年传奇；CUSBEA：风雨四十载；中国新药研发的焦虑；中国生物医药企业的研发竞争；中国双抗竞争格局；中国ADC竞争格局；中国双抗技术全梳理；中国ADC技术全梳理；Ambrx技术全梳理；Vir 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