Nuvation Bio启动第三阶段SIGMA试验，测试Safusidenib治疗IDH1突变型胶质瘤的效果Nuvation Bio Launches Phase 3 SIGMA Trial to Test Safusidenib for IDH1-Mutant Glioma

动脉网02-09

by GOAI由GOAI生成Share To分享到Nuvation Bio has initiated a pivotal global Phase 3 clinical trial, known as the SIGMA Trial (G203), to evaluate the efficacy and safety of safusidenib in patients with IDH1-...

网页链接

免责声明：本文观点仅代表作者个人观点，不构成本平台的投资建议，本平台不对文章信息准确性、完整性和及时性做出任何保证，亦不对因使用或信赖文章信息引发的任何损失承担责任。

精彩评论

我们需要你的真知灼见来填补这片空白

发表看法

{"i18n":{"language":"zh_CN"},"isChannel":false,"data":{"share":"https://www.laohu8.com/m/news/2610654558?lang=zh_CN&edition=full","thumbnail":"","is_english":false,"pubTime":"2026-02-09 22:15","share_image_url":"https://static.laohu8.com/9a95c1376e76363c1401fee7d3717173","id":"2610654558","market":"us","top_or_hot":-1,"title":"Nuvation Bio启动第三阶段SIGMA试验，测试Safusidenib治疗IDH1突变型胶质瘤的效果Nuvation Bio Launches Phase 3 SIGMA Trial to Test Safusidenib for IDH1-Mutant Glioma","media":"动脉网","content":"<div>\n<p>by GOAI由GOAI生成Share To分享到Nuvation Bio has initiated a pivotal global Phase 3 clinical trial, known as the SIGMA Trial (G203), to evaluate the efficacy and safety of safusidenib in patients with IDH1-...</p>\n\n<a href=\"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20260209221730a48f8fdc&s=b\">网页链接</a>\n\n</div>\n","source":"tencent","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Nuvation Bio启动第三阶段SIGMA试验，测试Safusidenib治疗IDH1突变型胶质瘤的效果Nuvation Bio Launches Phase 3 SIGMA Trial to Test Safusidenib for IDH1-Mutant Glioma</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nNuvation Bio启动第三阶段SIGMA试验，测试Safusidenib治疗IDH1突变型胶质瘤的效果Nuvation Bio Launches Phase 3 SIGMA Trial to Test Safusidenib for IDH1-Mutant Glioma\n</h2>\n\n<h4 class=\"meta\">\n\n\n2026-02-09 22:15 北京时间&nbsp;&nbsp;&nbsp;<a href=http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20260209221730a48f8fdc&s=b><strong>动脉网</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>by GOAI由GOAI生成Share To分享到Nuvation Bio has initiated a pivotal global Phase 3 clinical trial, known as the SIGMA Trial (G203), to evaluate the efficacy and safety of safusidenib in patients with IDH1-...</p>\n\n<a href=\"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20260209221730a48f8fdc&s=b\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4007","symbol_name":"制药","start_time":0,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20260209221730a48f8fdc&s=b","article_id":"2610654558","we_media_id":null,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20260209221730a48f8fdc&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, .wx-sou","directOrigin":true},"url":"https://stock-news.laohu8.com/highlight/detail?id=2610654558","pubTimestamp":1770646500,"columns":[],"sourceInfo":{"source_id":"tencent","name":"腾讯"},"weMediaInfo":null,"summary":"The SIGMA Trial will enroll participants globally and focus on individuals diagnosed with IDH1-mutant glioma. Safusidenib is designed to inhibit mutant IDH1 enzymes, which play a role in tumor growth by altering cellular metabolism. The study will measure key outcomes such as progression-free survival and overall survival rates among participants receiving safusidenib compared to those receiving standard treatment options.SIGMA 试验将在全球范围内招募参与者，并专注于确诊为 IDH1 突变型胶质瘤的个体。Safusidenib 旨在抑制突变的 IDH1 酶，这种酶通过改变细胞代谢在肿瘤生长中发挥作用。该研究将衡量接受 Safusidenib 的参与者与接受标准治疗的参与者之间的关键结果，如无进展生存期和总生存率。","collect":0,"end_time":0,"defaultTopTitle":"qq.com","property":[],"viewcount":null,"language":"zh","relate_stocks":{"BK4007":"制药","NUVB":"Nuvation Bio, Inc."},"translate_title":"Nuvation Bio launches Phase 3 SIGMA trial to test Safusidenib in IDH1 mutant glioma Nuvation Bio Launches Phase 3 SIGMA Trial to Test Safusidenib for IDH1-Mutant Glioma","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"NUVB":0.9},"content_text":"by GOAI由GOAI生成Share To分享到Nuvation Bio has initiated a pivotal global Phase 3 clinical trial, known as the SIGMA Trial (G203), to evaluate the efficacy and safety of safusidenib in patients with IDH1-mutant glioma. The announcement marks a significant step in the development of safusidenib, an investigational therapy targeting isocitrate dehydrogenase 1 (IDH1) mutations, which are commonly associated with certain types of gliomas.Nuvation Bio 已启动了一项关键的全球 III 期临床试验，称为 SIGMA 试验（G203），以评估 safusidenib 在 IDH1 突变型胶质瘤患者中的疗效和安全性。这一宣布标志着 safusidenib 开发迈出了重要一步，safusidenib 是一种针对异柠檬酸脱氢酶 1（IDH1）突变的在研疗法，该突变常与某些类型的胶质瘤相关。The trial aims to assess whether safusidenib can provide therapeutic benefits for patients with this specific genetic mutation..该试验旨在评估沙福西尼是否可以为具有这种特定基因突变的患者提供治疗益处。The SIGMA Trial will enroll participants globally and focus on individuals diagnosed with IDH1-mutant glioma. Safusidenib is designed to inhibit mutant IDH1 enzymes, which play a role in tumor growth by altering cellular metabolism. The study will measure key outcomes such as progression-free survival and overall survival rates among participants receiving safusidenib compared to those receiving standard treatment options.SIGMA 试验将在全球范围内招募参与者，并专注于确诊为 IDH1 突变型胶质瘤的个体。Safusidenib 旨在抑制突变的 IDH1 酶，这种酶通过改变细胞代谢在肿瘤生长中发挥作用。该研究将衡量接受 Safusidenib 的参与者与接受标准治疗的参与者之间的关键结果，如无进展生存期和总生存率。This Phase 3 trial follows earlier studies that evaluated the drug’s potential effectiveness and safety profile in treating IDH1-mutant cancers. Further details regarding enrollment criteria, locations, and timelines have not yet been disclosed..这项 III 期试验是在早期研究之后进行的，早期研究评估了该药物在治疗 IDH1 突变癌症中的潜在有效性和安全性。关于入组标准、地点和时间表的更多细节尚未披露。Newsflash | Powered by GeneOnline AI新闻快讯 | 由GeneOnline AI提供支持Source: GO-AI-ne1来源：GO-AI-ne1For any suggestion and feedback, please contact us.如有任何建议和反馈，请联系我们。Date: February 9, 2026日期：2026年2月9日©www.geneonline.com All rights reserved. Collaborate with us:©www.geneonline.com 版权所有。与我们合作：[email protected]电子邮件地址Author作者GOAIGOAIRelated Post相关文章","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"symbols":[],"gpt_button":1,"need_auth":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.36.2","shortVersion":"4.36.2","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2610654558","isCrawlerRequest":true}