歌礼制药-B(01672)：选定口服胰淀素受体激动剂多肽ASC36进行临床开发

智通财经02-11

智通财经APP讯，歌礼制药-B(01672)发布公告，公司董事会宣布已选定其首款口服胰淀素受体激动剂多肽ASC36口服片进行临床开发。歌礼预计将于2026年第二季度向美国食品药品监督管理局(FDA)递交ASC36口服片治疗肥胖症的新药临床试验申请(IND)。ASC36口服片由歌礼利用其专有的口服多肽递送增强技术(POTENT)开发而成。在非人灵长类动物中，10毫克ASC36口服片在每只动物中每日...

网页链接

免责声明：本文观点仅代表作者个人观点，不构成本平台的投资建议，本平台不对文章信息准确性、完整性和及时性做出任何保证，亦不对因使用或信赖文章信息引发的任何损失承担责任。

精彩评论

我们需要你的真知灼见来填补这片空白

发表看法

{"i18n":{"language":"zh_CN"},"isChannel":false,"data":{"share":"https://www.laohu8.com/m/news/2610057672?lang=zh_CN&edition=full","thumbnail":"","is_english":false,"pubTime":"2026-02-11 07:06","share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","id":"2610057672","market":"sh","top_or_hot":-1,"title":"歌礼制药-B(01672)：选定口服胰淀素受体激动剂多肽ASC36进行临床开发","media":"智通财经","content":"<div>\n<p>智通财经APP讯，歌礼制药-B(01672)发布公告，公司董事会宣布已选定其首款口服胰淀素受体激动剂多肽ASC36口服片进行临床开发。歌礼预计将于2026年第二季度向美国食品药品监督管理局(FDA)递交ASC36口服片治疗肥胖症的新药临床试验申请(IND)。ASC36口服片由歌礼利用其专有的口服多肽递送增强技术(POTENT)开发而成。在非人灵长类动物中，10毫克ASC36口服片在每只动物中每日...</p>\n\n<a href=\"http://www.zhitongcaijing.com/content/detail/1403931.html\">网页链接</a>\n\n</div>\n","source":"stock_zhitongcaijing","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>歌礼制药-B(01672)：选定口服胰淀素受体激动剂多肽ASC36进行临床开发</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\n歌礼制药-B(01672)：选定口服胰淀素受体激动剂多肽ASC36进行临床开发\n</h2>\n\n<h4 class=\"meta\">\n\n\n2026-02-11 07:06 北京时间&nbsp;&nbsp;&nbsp;<a href=http://www.zhitongcaijing.com/content/detail/1403931.html><strong>智通财经</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>智通财经APP讯，歌礼制药-B(01672)发布公告，公司董事会宣布已选定其首款口服胰淀素受体激动剂多肽ASC36口服片进行临床开发。歌礼预计将于2026年第二季度向美国食品药品监督管理局(FDA)递交ASC36口服片治疗肥胖症的新药临床试验申请(IND)。ASC36口服片由歌礼利用其专有的口服多肽递送增强技术(POTENT)开发而成。在非人灵长类动物中，10毫克ASC36口服片在每只动物中每日...</p>\n\n<a href=\"http://www.zhitongcaijing.com/content/detail/1403931.html\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"01477","symbol_name":"欧康维视生物-B","start_time":0,"source_url":"http://www.zhitongcaijing.com/content/detail/1403931.html","article_id":"2610057672","we_media_id":null,"thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2610057672","pubTimestamp":1770764769,"columns":[],"sourceInfo":{"source_id":"stock_zhitongcaijing","name":"智通财经网"},"weMediaInfo":null,"summary":"智通财经APP讯，歌礼制药-B 发布公告，公司董事会宣布已选定其首款口服胰淀素受体激动剂多肽ASC36口服片进行临床开发。歌礼预计将于2026年第二季度向美国食品药品监督管理局递交ASC36口服片治疗肥胖症的新药临床试验申请。ASC36片亦显著减少了食物摄入。与近期获FDA批准的一款GLP-1R激动剂多肽相比，凭借潜在更优的口服生物利用度和疗效，预计ASC36口服片的给药剂量更低。","collect":0,"end_time":0,"defaultTopTitle":"zhitongcaijing.com","property":[],"viewcount":null,"language":"zh","relate_stocks":{"01477":"欧康维视生物-B","BK1515":"抗疫概念","01672":"歌礼制药-B","BK1191":"制药","BK1161":"生物科技","BK1574":"生物医药B类股"},"translate_title":"Ascletis Pharmaceuticals-B (01672): Selected oral amylin receptor agonist polypeptide ASC36 for clinical development","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"01477":1.5,"01672":1.5},"content_text":"智通财经APP讯，歌礼制药-B(01672)发布公告，公司董事会宣布已选定其首款口服胰淀素受体激动剂多肽ASC36口服片进行临床开发。歌礼预计将于2026年第二季度向美国食品药品监督管理局(FDA)递交ASC36口服片治疗肥胖症的新药临床试验申请(IND)。ASC36口服片由歌礼利用其专有的口服多肽递送增强技术(POTENT)开发而成。在非人灵长类动物中，10毫克ASC36口服片在每只动物中每日一次给药，给药7天后，稳态下的绝对口服生物利用度(absolute oral bioavailability)[1]为8%，消除半衰期(elimination half-life)达116小时;25毫克ASC36口服片在每只动物中每日一次给药，给药7天后，稳态下的绝对口服生物利用度为6%，消除半衰期达167小时。ASC36口服片较长的消除半衰期(116小时至167小时)，为每日一次及更低频率的口服给药方案提供了支持。ASC36口服片在非人灵长类动物和饮食诱导肥胖(DIO)大鼠模型中均表现出了显著的减重效果。在非人灵长类动物中，ASC36口服片每日一次给药7天后，使相对基线的平均体重下降高达13.2%。ASC36片亦显著减少了食物摄入。在一项头对头DIO大鼠模型中，治疗7天后，与eloralintide和petrelintide相比， ASC36实现的减重效果分别相对提升约32%和91%。与近期获FDA批准的一款GLP-1R激动剂多肽相比，凭借潜在更优的口服生物利用度和疗效，预计ASC36口服片的给药剂量更低。每毫克ASC36多肽更优越的减重效果，也可能使其在规模化生产中成本更低(scalability advantages in manufacturing)。ASC36是一款利用歌礼基于结构的AI辅助药物发现(Artificial Intelligence-assisted Structure-Based Drug Discovery，AISBDD)技术自主研发的胰淀素受体激动剂多肽。ASC36口服片剂由歌礼利用其专有的POTENT技术开发并优化而成，该技术用于实现口服多肽递送。“我们有三个关键的胰淀素候选药物：口服小分子胰淀素、口服胰淀素多肽和每月一次皮下注射胰淀素多肽，ASC36口服片是其中一款重要的胰淀素激动剂，”歌礼创始人、董事会主席兼首席执行官吴劲梓博士表示，“依托我们的三大专有技术平台，包括AISBDD、超长效药物开发平台(Ultra-Long-Acting Platform，ULAP)和POTENT，歌礼已成功构建了一个极具竞争力、差异化且多元化的产品管线组合，有望有效应对肥胖及其他代谢疾病患者多样化的治疗需求。”","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"symbols":[],"gpt_button":1,"need_auth":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.36.2","shortVersion":"4.36.2","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2610057672","isCrawlerRequest":true}