康诺亚 TSLP 单抗启动新 III 期，石药拥有权益

丁香园 Insight 数据库02-05

药物临床试验登记与信息公示平台官网显示，康诺亚登记了一项评价 CM326 重组人源化单克隆抗体注射液治疗慢性鼻窦炎伴鼻息肉患者的有效性、安全性的多中心、随机、双盲、安慰剂平行对照的 III 期临床试验（登记号：CTR20260394）。来源：药物临床试验登记与信息公示平台官网该研究计划纳入212 名受试者，随机分组接受 CM326 和安慰剂治疗，每 4 周给药一次，双盲治疗期内共给药 6 次，开放...

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次，开放标签治疗期内共给药 7 次。主要终点是治疗第 24 周时，鼻息肉评分（NPS）较基线的变化，以及鼻塞评分（NCS）较基线的变化。CM326 是由康诺亚研发的具有全新作用机制的 1 类创新药，靶向胸腺基质淋巴细胞生成素（TSLP）。TSLP 是炎症级联反应的启动因子之一，抑制 TSLP 可以从炎症发生的早期进行干预，阻止免疫细胞释放促炎细胞因子。目前，CM326 正在开展多项临床研究，适应症包括哮喘、慢性鼻窦炎伴鼻息肉病、特应性皮炎和慢性阻塞性肺病。其中哮喘已经推进至 III 期临床研究。2021 年 11 月，康诺亚与石药集团达成合作，将 CM326 在中重度哮喘和慢性阻塞性肺病等呼吸系统疾病开发及商业化权益独家授予后者。2024 年 11 月，康诺亚同意扩大授予石药集团的特许权使用领域至所有适应症。封面来源：企业logo","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":1,"need_auth":false,"need_login_tip":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; 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