查尔斯河与加齐大学合作进行基因治疗制造Charles River Partners with Gazi University on Gene Therapy Manufacturing

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Charles River Laboratories International has entered into a manufacturing collaboration with the Faculty of Medicine at Gazi University to support the development of a gene therapy programme focused ...

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These deposits can cause inflammation, pain, and restricted movement.合作的重点是对高磷血症性肿瘤样钙质沉着症 (HTC) 的研究，这是一种罕见的遗传性疾病，其特征是血液中磷酸盐水平升高，并在软组织（尤其是主要关节周围）形成疼痛的磷酸钙沉积。这些沉积物可能引发炎症、疼痛和活动受限。Researchers at Gazi University have identified defects in the GALNT3 gene as a key cause of the disorder..加齐大学的研究人员已确定GALNT3基因的缺陷是该疾病的一个关键原因。As part of the agreement, Charles River will supply pre-manufactured, research-grade AAV plasmids to support early-stage gene therapy development. These plasmids are produced using animal component-free processes and are designed to be ready for immediate use. The approach is intended to help academic researchers advance programmes more efficiently while managing development timelines and costs..根据协议，查尔斯河将提供预先制造的、研究级别的AAV质粒，以支持早期基因治疗开发。这些质粒采用无动物成分的工艺生产，并设计为可立即使用。该方法旨在帮助学术研究人员更高效地推进项目，同时管理开发时间和成本。The partnership brings together academic expertise in rare disease genetics with industrial capabilities in cell and gene therapy manufacturing. It is expected to support the translation of laboratory research into potential therapeutic solutions for patients with limited treatment options.该合作将罕见病遗传学的学术专业知识与细胞和基因治疗制造的工业能力相结合。预计它将支持实验室研究转化为针对治疗选择有限的患者的潜在治疗方案。The company provides integrated solutions across the development lifecycle, from preclinical research through to commercial-scale production of plasmid DNA, viral vectors, and cell-based therapies.该公司提供贯穿开发生命周期的综合解决方案，从临床前研究一直到质粒DNA、病毒载体和细胞疗法的商业化规模生产。Charles River continues to expand its cell and gene therapy CDMO offering, which spans discovery support, safety assessment, biologics testing, and manufacturing services.查尔斯河继续扩展其细胞和基因治疗CDMO服务，涵盖发现支持、安全性评估、生物制品测试及生产服务。Source: criver.com来源：criver.com","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"corporation","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":1,"need_auth":false,"need_login_tip":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.42.0","shortVersion":"4.42.0","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2605949958","isCrawlerRequest":true}