JPM：Illumina推出“前所未有的”疾病生物学图谱JPM: Illumina launches 'unprecedented' disease biology atlas

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Illumina has unveiled a database of genomic alterations, called the Billion Cell Atlas, that can be used to identify and validate drug targets and train AI models used in drug discovery.Illumina 发布了一个...

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Pharma groups AstraZeneca, MSD, and Eli Lilly have partnered with该疾病生物学工具的首个迭代版本在旧金山的摩根大通医疗保健会议上首次亮相，该工具将在三年内扩展到包含50亿个细胞。阿斯利康、默克和礼来等制药集团已与之合作。Illumina因美纳on the resource.在资源上。According to the gene sequencing specialist, the Atlas is already the world's largest genome据基因测序专家介绍，Atlas已经是世界上最大的基因组‑‑wide genetic perturbation dataset, currently drawn from sequence data from 150 million cells. It uses CRISPR to switch on and off 20,000 genes across 250 disease-relevant human cell types to build a map of biological activity in health and disease.来自1.5亿个细胞的序列数据组成的广泛基因扰动数据集。它利用CRISPR技术开启和关闭250种与疾病相关的人类细胞类型中的2万个基因，以构建健康和疾病状态下的生物活动图谱。The cell lines chosen for the project include historically hard-to-decode cells involved in cardiometabolic disease, neurological disease, immune disorders, rare genetic diseases, and cancer, said the company.公司表示，该项目选择的细胞系包括历史上难以解码的细胞，这些细胞与心脏代谢疾病、神经系统疾病、免疫疾病、罕见遗传疾病和癌症有关。The launch is a pivotal moment for Illumina, broadening its historic focus on next-generation sequencing (NGS) of DNA and building on its recently set up此次发布是Illumina的一个关键时刻，拓宽了其对DNA下一代测序（NGS）的历史关注，并在其最近建立的基础上进一步发展。BioInsight生物洞察business unit, which is tasked with developing data assets, software, and AI for life science research and expanding pharma access to multiomics data.业务部门，该部门负责为生命科学研究开发数据资产、软件和人工智能，并扩大制药行业对多组学数据的访问。A key part of BioInsight is to work with industry partners on large-scale genetic and biological data generation projects, and the Atlas is the first fruit of that initiative.BioInsight 的一个关键部分是与行业合作伙伴在大规模基因和生物数据生成项目上合作，而 Atlas 是该计划的第一个成果。'We believe the cell atlas is a key development that will enable us to significantly scale AI for drug discovery,' said Jacob Thaysen, Illumina's chief executive.“我们相信，细胞图谱是一项关键的发展，它将使我们能够显著扩大AI在药物发现中的应用，”Illumina首席执行官Jacob Thaysen表示。'We are building an unparalleled resource for training the next generation of AI models for precision medicine and drug target identification, ultimately helping map the biological pathways behind some of the world's most devastating diseases,' he added.“我们正在构建一个无与伦比的资源，用于训练下一代人工智能模型，以实现精准医学和药物靶点识别，最终帮助绘制出一些世界上最致命疾病的生物学通路，”他补充道。At JPM, Thaysen said that Illumina's future lies in finding growth from three areas: sequencing, multiomics, and expansion of services into data and software for drug discovery and clinical translation through BioInsight. The company returned to growth in 2025 after seeing several years of declining revenues caused by a mature sequencing market and increased competition..在摩根大通医疗健康年会上，赛森表示，Illumina 的未来在于从三个领域寻找增长：测序、多组学以及通过 BioInsight 将服务扩展到药物发现和临床转化的数据和软件。在经历了因测序市场成熟和竞争加剧导致的多年收入下滑后，该公司于 2025 年恢复增长。MSD – known as Merck & Co in the US and Canada – has already started using the Atlas in its drug discovery operations, for example, to train its AI foundation models and build 'virtual cells' that can be used to study disease.默沙东（在美国和加拿大称为默克公司）已经开始在其药物研发业务中使用Atlas，例如训练其人工智能基础模型，构建可用于研究疾病的“虚拟细胞”。The partners say the technology – which will be offered to additional companies – can enable users to characterise drug and disease mechanisms of action, explore potential new indications for therapeutics, and validate candidate targets from human genetics.合作伙伴表示，这项将提供给更多公司的技术能够使用户描述药物和疾病的作用机制，探索治疗的潜在新适应症，并从人类遗传学中验证候选靶点。'We're establishing a scalable bridge from genomic insight to therapeutic impact, accelerating the path from discovery to the clinic and enabling a deeper understanding of complex disease biology with unprecedented confidence and speed.'“我们正在建立一座从基因组洞察到治疗影响的可扩展桥梁，加速从发现到临床的路径，并以空前的信心和速度加深对复杂疾病生物学的理解。”","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":1,"need_auth":false,"need_login_tip":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.42.0","shortVersion":"4.42.0","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2603862386","isCrawlerRequest":true}