礼来(LLY.US)“减肥神药”联合疗法显奇效，免疫疾病治疗版图加速扩张

智通财经01-09

智通财经APP获悉，礼来公司(LLY.US)最新研究显示，将其广受欢迎的减肥注射药物Zepbound与关节炎药物Taltz联合使用，在缓解关节疼痛和肿胀方面展现出优于单一疗法的显著效果。这项由礼来支持的研究，为GLP-1类药物在炎症及自身免疫疾病领域的应用开辟了新战线。该研究招募了271名患有肥胖和活动性银屑病关节炎的患者。结果显示，联合疗法在帮助患者减重和控制关节炎方面，效果优于单独使用...

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territory","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"LLY":1.98},"content_text":"智通财经APP获悉，礼来公司(LLY.US)最新研究显示，将其广受欢迎的减肥注射药物Zepbound与关节炎药物Taltz联合使用，在缓解关节疼痛和肿胀方面展现出优于单一疗法的显著效果。这项由礼来支持的研究，为GLP-1类药物在炎症及自身免疫疾病领域的应用开辟了新战线。该研究招募了271名患有肥胖和活动性银屑病关节炎的患者。结果显示，联合疗法在帮助患者减重和控制关节炎方面，效果优于单独使用Taltz，这符合试验的主要目标。礼来在声明中称，约三分之一的联合用药患者其银屑病关节炎症状减轻了至少一半，而单用Taltz的患者中这一比例为20.4%。像Zepbound这类GLP-1受体激动剂，已被证明能降低糖尿病和肥胖患者的炎症水平。观察性研究和病例报告甚至曾将其与银屑病等自身免疫疾病的改善相关联，而此次研究首次为这一理论提供了验证。随着肥胖药物市场预计到2030年将达到千亿美元规模，Zepbound的吸引力部分在于其解决其他健康问题的潜力，包括睡眠呼吸暂停和心力衰竭。礼来已将这种思路融入其下一代减肥药retatrutide的研发中，该药正在针对膝骨关节炎和慢性肾病等病症进行研究。礼来表示，计划与药品监管机构讨论该研究结果，此举可能导致其药品标签适应症扩大或临床治疗建议的修改。在美国，约65%的银屑病关节炎成人患者伴有肥胖，这意味着其中大多数人本身已符合Zepbound的治疗条件。这家总部位于印第安纳波利斯的制药巨头还在探索Zepbound与Taltz联合治疗斑块状银屑病和炎症性肠病的疗效。礼来表示，斑块状银屑病的试验结果预计将在今年上半年公布。Taltz是礼来旗下数款治疗关节炎和银屑病等炎症性疾病的药物之一，年销售额已超过30亿美元，但其关键专利保护将在未来几年内到期。与Zepbound的联合研究，是礼来利用其在肥胖症领域的成功来推动免疫学等其他业务增长的战略组成部分。该公司也在积极寻求交易以扩充产品管线。周三，礼来宣布将以高达12亿美元的价格收购Ventyx Biosciences，从而获得针对炎症性疾病的口服疗法。此举建立在早期对Morphic 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