超1亿美元！蛋白降解剂“吸金”，强生、诺华、谷歌都来了

医药魔方01-09

1月9日，致力于开发细胞外蛋白降解剂的EpiBiologics宣布完成1.07亿美元B轮融资，本轮融资由Google Ventures及Johnson & Johnson Innovation领投，Novartis Venture Fund等新投资者及Polaris Partners等现有投资者跟投。融资收益将用于推进EpiBiologics的新型双特异性抗体管线，以选择性地降解肿瘤和免疫疾病中的...

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Protein degraders \"absorb gold\", Johnson & Johnson, Novartis, and Google are all here","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"GOOGL":0.9,"NVS":1.89,"JNJ":1.91,"USJW.SI":0.6,"GOOG":0.9},"content_text":"1月9日，致力于开发细胞外蛋白降解剂的EpiBiologics宣布完成1.07亿美元B轮融资，本轮融资由Google Ventures及Johnson & Johnson Innovation领投，Novartis Venture Fund等新投资者及Polaris Partners等现有投资者跟投。融资收益将用于推进EpiBiologics的新型双特异性抗体管线，以选择性地降解肿瘤和免疫疾病中的致病膜蛋白和可溶性蛋白。公司先导项目EPI-326是一种组织选择性双特异性抗体，被开发用于治疗EGFR驱动的癌症， 可降解所有致癌形式的EGFR，克服现有EGFR疗法的局限性，同时，该疗法将降解定位于肿瘤，不影响正常健康组织。在临床前研究中，EPI-326展示出了强大而持久的疗效，且具有良好的安全性和药代动力学，可用于多种癌症类型的单药治疗和联合治疗。EpiBiologics计划在2026年初启动EPI-326治疗非小细胞肺癌和头颈部鳞状细胞癌的首次人体（First-in-human）临床试验。EpiBiologics成立于2022年，总部位于旧金山，致力于推进下一代靶向膜蛋白及可溶性蛋白的蛋白降解管线与平台，于2023年完成7300万美元A轮及A+轮融资，加上此次的B轮融资已经累计融资1.8亿美元。以PROTAC、分子胶为代表的靶向蛋白降解技术（TPD），能够通过诱导靶蛋白与泛素-蛋白酶体系统接近并促使其降解，但受限于蛋白酶体系统的空间定位，这些技术局限于胞内靶点，无法有效降解膜蛋白与胞外蛋白（近40%基因编码的蛋白是膜蛋白与胞外蛋白，它们在细胞信号转导、免疫应答、物质运输以及细胞间通讯等关键生理与病理过程中发挥着不可或缺的作用，是众多疾病治疗的重要靶点）。EpiBiologics在科学创始人、加州大学旧金山分校Jim Wells博士的开创性工作基础上成立，核心技术为EpiTAC平台，这是一种模块化的双特异性抗体系统，能够以组织特异性的方式靶向降解疾病驱动细胞外蛋白。其中，AbTAC将靶蛋白与跨膜E3连接酶结合在一起，通过蛋白酶体驱动泛素化和膜蛋白降解。KineTAC利用由趋化因子或细胞因子受体驱动的自然内化过程，通过天然配体与受体结合，驱动可溶性蛋白和膜蛋白的内化和溶酶体降解。TrainTAC利用广泛的内化受体将膜蛋白和可溶性细胞外蛋白转运到溶酶体进行降解。EpiBiologics正在基于EpiTAC开发first-in-class及best-in-class靶向疗法，涉及肿瘤、免疫疾病等领域。在2025年AACR大会上，公司首次公布了c-Met EpiTAC双特异性抗体降解剂的临床前数据。数据显示，c-Met EpiTAC在体内表现出强劲的抗肿瘤活性。参考资料：[1]https://www.epibiologics.com/news-publications/epibiologics-closes-107m-series-b-to-advance-pipeline-of-novel-bispecific-antibodies-to-selectively-degrade-extracellular-protein-targets-in-oncology-and-immunology[2]https://www.epibiologics.com/[3]https://www.epibiologics.com/news-publications/epibiologics-presents-first-data-on-c-met-degrading-bispecific-antibody","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"corporation","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":0,"need_auth":false,"need_login_tip":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.42.0","shortVersion":"4.42.0","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2602322575","isCrawlerRequest":true}