13亿美元！礼来AI制药重磅合作，事关减肥药！

智药局01-07

近日，全球市值最高药企礼来与计算化学公司Nimbus Therapeutics合作，聚焦于备受关注的口服肥胖疗法研发领域。最新的合作，礼来将支付给Nimbus最高5500万美元的预付款和近期里程碑付款，用于利用这家生物技术公司的计算化学和基于结构的药物设计方法，开发一种针对肥胖及其他代谢疾病的新型口服治疗方案。未来，如果口服药物上市Nimbus可能获得高达13亿美元的开发、商业和销售里程碑付款，...

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Eli Lilly AI Pharmaceuticals' blockbuster cooperation is related to weight loss pills!","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"LLY":1.91},"content_text":"近日，全球市值最高药企礼来与计算化学公司Nimbus Therapeutics合作，聚焦于备受关注的口服肥胖疗法研发领域。最新的合作，礼来将支付给Nimbus最高5500万美元的预付款和近期里程碑付款，用于利用这家生物技术公司的计算化学和基于结构的药物设计方法，开发一种针对肥胖及其他代谢疾病的新型口服治疗方案。未来，如果口服药物上市Nimbus可能获得高达13亿美元的开发、商业和销售里程碑付款，以及全球净销售的分级版税。值得一提的是，该协议是在一项基础上的扩大合作。2022年10月，礼来和Nimbus宣布，共同探索激活特定抗菌肽激活蛋白激酶（AMPK）亚型用于代谢疾病的新型靶向疗法，合作总额高达4.96亿美元。Nimbus Therapeutics研发总裁Peter Tummino博士表示：“在Nimbus，计算科学家、药物化学家、药理学家和转化生物学家共同合作，将AI驱动的预测模型与结构设计相结合，开发具有顶级潜力的新型小分子。这种整合使我们能够持续交付针对难以药物化靶点优化的临床候选药物。”Nimbus Therapeutics，最早由Bruce Booth和Ramy Farid于2009年在美国创立。Nimbus 将领先的计算技术与一系列量身定制的基于机器学习的预测建模方法相结合，针对一些难成药靶点发现和开发新型小分子药物。截止目前，Nimbus已经完成9轮融资，总金额达到6.37亿美元，盖茨基金已经6次下注，投资方名单里还不乏礼来风投、辉瑞风投及首家AI制药上市公司Schrödinger等知名机构，金主阵容十分豪华。2022年12月14日，武田以60亿美元预付款收购了一款晚期TYK2抑制剂（后被武田命名为TAK-279），其中包括40亿美元的预付款以及20亿美元的商业里程碑。近期，武田制药宣布，其高选择性口服TYK2抑制剂Zasocitinib（TAK-279）在两项关键3期临床试验中取得积极结果。基于Zasocitinib强效和安全性表现，武田计划2026财年提交新药上市申请。\n\n\n海量资讯、精准解读，尽在新浪财经APP","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"2","news_tag":"","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.36.2","shortVersion":"4.36.2","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2601874409","isCrawlerRequest":true}