港股异动 | 亚盛医药-B(06855)涨超3% 首次揭示奥雷巴替尼通过调控脂质代谢发挥抗肿瘤作用全新机制

智通财经11-26

智通财经APP获悉，亚盛医药-B(06855)涨超3%，截至发稿，涨3.04%，报64.35港元，成交额4604.84万港元。

消息面上，据亚盛医药官微消息，11月25日，亚盛医药宣布，公司原创1类新药奥雷巴替尼(商品名：耐立克^®)治疗胃肠道间质瘤(GIST)的转化医学和Ib期临床试验(NCT03594422)的研究成果日前在国际权威期刊《信号传导与靶向治疗》(Signal Transduction and Targeted Therapy，影响因子52.7)成功发表。研究结果表明奥雷巴替尼在琥珀酸脱氢酶(SDH)缺陷型GIST中具有良好的疗效与安全性，并首次揭示奥雷巴替尼通过调控脂质代谢发挥抗肿瘤作用的全新机制。

本项I期研究评估了奥雷巴替尼在66例不可切除/转移性GIST/其他实体瘤患者中的安全性和抗肿瘤活性，其中包括26例酪氨酸激酶抑制剂(TKI)治疗失败的SDH缺陷型GIST患者。据悉，这是迄今为止针对该罕见GIST亚型规模最大的前瞻性临床试验。

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