创新药重磅! Arvinas(ARVN.US)携辉瑞(PFE.US)推进“乳腺癌ER降解剂”第三方商业化

智通财经2025-09-18

智通财经APP获悉，美国生物科技新势力Arvinas(ARVN.US)以及合作伙伴医药巨头辉瑞(PFE.US)已决定将重磅创新药vepdegestrant 的商业化权利对外授权——即决定将该药物的商业化权利对外转授权，该药是一种用于乳腺癌的在研雌激素受体蛋白降解剂(乳腺癌ER降解剂)。其批准申请已于6月提交美国食品药品监督管理局(FDA)。据了解，Arvinas 在一份新闻稿中表示，授权交由第三方...

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Arvinas (ARVN.US) and Pfizer (PFE.US) promote third-party commercialization of \"breast cancer ER degrader\"","themeId":"3d5e617fa4201a4d118497eca86af802","isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"159992":1.5,"ARVN":1.5,"06978":1.5,"PFE":1.5},"content_text":"智通财经APP获悉，美国生物科技新势力Arvinas(ARVN.US)以及合作伙伴医药巨头辉瑞(PFE.US)已决定将重磅创新药vepdegestrant 的商业化权利对外授权——即决定将该药物的商业化权利对外转授权，该药是一种用于乳腺癌的在研雌激素受体蛋白降解剂(乳腺癌ER降解剂)。其批准申请已于6月提交美国食品药品监督管理局(FDA)。据了解，Arvinas 在一份新闻稿中表示，授权交由第三方的商业化举措“是释放vepdegestrant的全部价值并确保若获监管机构批准即可及时向市场供应的最佳前进路径”。Arvinas与辉瑞联合表示，决定将其产品、技术或知识产权的开发、生产、营销/商业化等权利授予第三方(licensee)，由对方推进并按约支付预付款、里程碑金与版税等回报。该项举措在全球医药行业尤常见，比如把某一药物在特定地区或全球的商业化权利对外授权。Arvinas 表示，鉴于 vepdegestrant 项目的重大变更，该公司将裁员15%，寻求更大的战略性业务发展机遇，并识别更多提效空间。据悉，有资料显示，该公司有三款处于一期临床阶段的重要候选药物：ARV-102(主要用于进行性核上性麻痹和帕金森病);ARV-393(用于非霍奇金淋巴瘤);以及 ARV-806(用于实体瘤恶性肿瘤)。生物科技新势力Arvinas是什么来头?引起轰动的vepdegestrant是什么?总部位于美国，纳斯达克代码ARVN的临床阶段生物科技公司Arvinas以靶向蛋白降解(TPD)为核心，使用自研PROTAC平台打造“全新类别”的药物，围绕靶向蛋白降解嵌合体(PROTAC)平台推进肿瘤等领域管线并对外合作开发与商业化——比如与辉瑞在乳腺癌项目上合作，与美国医药巨头辉瑞联合开发的创新药物vepdegestrant乃Arvinas当前的旗舰创新药项目与主要价值驱动。vepdegestrant(ARV-471) 是口服的 PROTAC 雌激素受体(ER)降解剂，用于 ER+/HER2- 局部晚期或转移性乳腺癌;分子一端结合ER，另一端招募结合E3泛素连接酶(如 cereblon)，诱导 ER 泛素化并经蛋白酶体降解。最新资料显示，vepdegestrant已获FDA快速通道资格;2025年NDA(新药上市申请) 已提交并被FDA接受，8月获FDA受理进入审评阶段——是Arvinas公司离上市最近的项目，当前仍然处于审评阶段;Arvinas/辉瑞最新决定将其商业化权利对外转授权。vepdegestrant 是口服 PROTAC(靶向蛋白降解)雌激素受体降解剂，通过结合E3连接酶将ER打上“降解标签”并由蛋白酶体清除，与传统 SERD/拮抗剂“仅阻断受体”截然不同，属具备突破意义的创新药物类型。","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.36.2","shortVersion":"4.36.2","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2568942697","isCrawlerRequest":true}