AD：急性肠炎促进阿尔茨海默病毒蛋白清除？哈佛团队的最新发现令人吃惊

亿欧网2025-06-11

哈佛医学院的研究团队在《Alzheimer's & Dementia》期刊上发表了一项出人意料的研究成果，揭示了急性肠炎对阿尔茨海默病（AD）病理的影响。研究使用5xFAD小鼠模型，通过葡聚糖硫酸钠盐（DSS）诱导急性结肠炎，发现尽管肠道微生物失衡和全身性炎症加剧，但小鼠脑内的Aβ沉积却减少，且Aβ向血液中的外流增加。这一结果与普遍认为的肠道疾病促进AD进展的观点相悖。研究还显示，急性结肠炎导致...

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