溢价246%收购！赛诺菲剑指武田、艾伯维折戟的靶点

药时代2025-05-27

正文共2000字 2图预计阅读时间5分钟在2025年5月22日，全球医药巨头赛诺菲（Sanofi）宣布了一项重要决定：以每股8美元现金的价格，总额约4.7亿美元收购Vigil Neuroscience。这一价格显著高于Vigil Neuroscience目前1.15亿美元的市值，溢价高达246%。这次收购的核心在于VG-3927，一种针对骨髓细胞表达触发受体2（TREM2）的口服小分子激动剂，用于...

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Sanofi's sword targets Takeda and AbbVie's halberds","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"ABBV":0.9,"ARIA":1,"VG":0.9,"PAM":1},"content_text":"正文共2000字 2图预计阅读时间5分钟在2025年5月22日，全球医药巨头赛诺菲（Sanofi）宣布了一项重要决定：以每股8美元现金的价格，总额约4.7亿美元收购Vigil Neuroscience。这一价格显著高于Vigil Neuroscience目前1.15亿美元的市值，溢价高达246%。这次收购的核心在于VG-3927，一种针对骨髓细胞表达触发受体2（TREM2）的口服小分子激动剂，用于治疗包括阿尔茨海默病（AD）在内的神经退行性疾病。该药物预计将在今年下半年进入II期临床试验。图片来源：sanofi官网在TREM2靶点中突破重围为何赛诺菲愿意溢价246%收购一家AD新药公司呢？让我们先了解一下它的核心产品吧。口服小分子TREM2激动剂VG-3927旨在增强小胶质细胞对聚集淀粉样蛋白和tau的保护性反应，同时不增加炎症反应。基于其激动剂和正变构调节剂（PAM）的新型作用模式，可能会放大VG-3927在病灶部位的作用，从而强烈调节小胶质细胞并可能增强神经保护。由于VG-3927不与sTREM2结合，与抗体TREM2激动剂相比，该疗法可最大限度地提高受体活化和小胶质细胞功能，这可能会增加其进入AD病灶的机会。此外，VG-3927没有Fc结构域，该结构域与免疫系统中与淀粉样蛋白相关成像异常（ARIA）风险增加相关的元素有关。图片来源：Vigil Neuroscience披露资料在今年年初，Vigil Neuroscience公布了VG-3927用于阿尔茨海默病的一期临床试验结果。VG-3927在患者脑脊液中实现了高达约50%的游离TREM2（sTREM2）显著剂量依赖性降低，且显示出高脑外显率、可耐受的安全性。这意味着，VG-3927作为全球首款用于AD治疗、目前临床进展最快的口服小分子TREM2激动剂，证明了TREM2这条通路用于治疗AD的可行性。值得一提的是，考虑到其他竞争对手如武田与Denali共同开发的单抗NL919、艾伯维与Alector共同开发的单克隆抗体AL002等TREM2靶向药物相继折戟的背景下，VG-3927的积极数据显得尤为突出，对CNS领域的研究者有着借鉴与鼓舞的作用。此外，VG-3927还是TREM2赛道中唯三治疗CNS适应症的临床阶段项目，并取得了积极的临床数据（其余两款为诺华自主研发的单抗VHB937、安进原研、已授权给Vigil的单抗VGL101），这或许也是赛诺菲砸下重金的关键原因。更何况VG-3927还有一个亮点，是以上管线中唯一一款口服小分子TREM2激动剂，可实现每日1次给药。口服剂型将成为AD研发next level近年来，随着Aduhelm、Leqembi以及Donanemab等药物的相继获批，AD药物的研发进入了快速发展阶段。然而，这些新批准的药物在商业化过程中面临着一系列挑战，特别是与输液相关的基础设施需求。例如，Leqembi需要每月两次给药，并且患者必须在专科中心接受输液治疗。目前，在研的AD药物中，上市的口服剂型相对较少。首款FDA批准的口服AD药物是2014年的美金刚/多奈哌齐复方制剂，而直到2024年第二款药物Zunveyl才获得批准。2025年1月8日，康哲宣布获得了Zunveyl在亚洲（除日本）、澳大利亚和新西兰的独家权益，协议总金额达到4000万美元。这一动态表明，尽管存在挑战，但口服AD药物因其便利性和潜在的市场吸引力，正逐渐成为研发的next level。VG-3927在此领域的领先优势获得了赛诺菲的青睐。结语：综上所述，赛诺菲对Vigil Neuroscience的收购标志着其在神经病学领域的关键战略布局，成功将具有潜力的阿尔茨海默病口服小分子药物VG-3927纳入麾下。凭借其独特的作用机制、积极的临床数据以及口服剂型所带来的优势，此次收购有望为赛诺菲开辟新的增长点，并为全球阿尔茨海默病患者提供新的治疗希望。随着VG-3927二期临床试验的推进，其能否实现创新突破并改变AD治疗格局，值得行业持续关注。参考资料：1.https://www.vigilneuro.com/trem22.https://www.sanofi.cn/zh3.https://www.biospace.com/deals/sanofi-buys-vigil-for-470m-upfront-reigniting-a-battered-alzheimers-target4.其他公开资料图片来源：豆包AI突破的力量：这家跨国药企如何用4年成为中国医药创新 “造氧机”？2025-05-26中国创新药出海排行榜（征求意见稿）2025-05-25超越·盈领｜2025诺和诺德首届肥胖症论坛璀璨落幕，擘画肥胖管理新篇章2025-05-24版权声明/免责声明本文为原创文章。本文仅作信息交流之目的，不提供任何商用、医用、投资用建议。文中图片、视频、字体、音乐等素材或为药时代购买的授权正版作品，或来自微信公共图片库，或取自公司官网/网络，部分素材根据CC0协议使用，版权归拥有者，药时代尽力注明来源。如有任何问题，请与我们联系。衷心感谢!药时代官方网站:www.drugtimes.cn联系方式:电话:13651980212微信:27674131邮箱:contact@drugtimes.cn点击这里，查看更多精彩！","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"2","news_tag":"corporation,merge","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":1,"need_auth":false,"need_login_tip":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"tenantId":"TBCN","deviceId":"web-server-community-laohu8-v3","version":"4.42.3","shortVersion":"4.42.3","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2538281482","isCrawlerRequest":true}