吉利德彻底放弃CD47单抗开发

医药魔方04-26

4月22日，吉利德在公布2024Q1财报的同时，更新了管线进展，其将关于CD47单抗magrolimab的6项试验从管线中剔除。包括magrolimab联合疗法治疗头颈部鳞状细胞癌、三阴性乳腺癌、结直肠癌等多种实体瘤研究。今年2月7日，吉利德宣布，终止magrolimab所有血液瘤项目开发，短短10天后，其又宣布magrolimab实体瘤临床试验遭FDA暂停。而此次6项试验从管线中移除意味着吉利德...

网页链接

免责声明：本文观点仅代表作者个人观点，不构成本平台的投资建议，本平台不对文章信息准确性、完整性和及时性做出任何保证，亦不对因使用或信赖文章信息引发的任何损失承担责任。

精彩评论

我们需要你的真知灼见来填补这片空白

发表看法

{"i18n":{"language":"zh_CN"},"isChannel":false,"data":{"share":"https://www.laohu8.com/m/news/2430261205?lang=zh_CN&edition=full","thumbnail":"","is_english":false,"pubTime":"2024-04-26 07:54","share_image_url":"https://static.laohu8.com/9a95c1376e76363c1401fee7d3717173","id":"2430261205","market":"us","top_or_hot":-1,"title":"吉利德彻底放弃CD47单抗开发","media":"医药魔方","content":"<div>\n<p>4月22日，吉利德在公布2024Q1财报的同时，更新了管线进展，其将关于CD47单抗magrolimab的6项试验从管线中剔除。包括magrolimab联合疗法治疗头颈部鳞状细胞癌、三阴性乳腺癌、结直肠癌等多种实体瘤研究。今年2月7日，吉利德宣布，终止magrolimab所有血液瘤项目开发，短短10天后，其又宣布magrolimab实体瘤临床试验遭FDA暂停。而此次6项试验从管线中移除意味着吉利德...</p>\n\n<a href=\"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN2024042607571787b0f7e6&s=b\">网页链接</a>\n\n</div>\n","source":"tencent","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>吉利德彻底放弃CD47单抗开发</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\n吉利德彻底放弃CD47单抗开发\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-04-26 07:54 北京时间&nbsp;&nbsp;&nbsp;<a href=http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN2024042607571787b0f7e6&s=b><strong>医药魔方</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>4月22日，吉利德在公布2024Q1财报的同时，更新了管线进展，其将关于CD47单抗magrolimab的6项试验从管线中剔除。包括magrolimab联合疗法治疗头颈部鳞状细胞癌、三阴性乳腺癌、结直肠癌等多种实体瘤研究。今年2月7日，吉利德宣布，终止magrolimab所有血液瘤项目开发，短短10天后，其又宣布magrolimab实体瘤临床试验遭FDA暂停。而此次6项试验从管线中移除意味着吉利德...</p>\n\n<a href=\"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN2024042607571787b0f7e6&s=b\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU1585245621.USD","symbol_name":"EASTSPRING INV GLOBAL LOW VOLATILITY EQUITY FUND \"A\" (USD) ACC B","start_time":0,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN2024042607571787b0f7e6&s=b","article_id":"2430261205","we_media_id":null,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN2024042607571787b0f7e6&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, .wx-sou","directOrigin":true},"url":"https://stock-news.laohu8.com/highlight/detail?id=2430261205","pubTimestamp":1714089256,"sourceInfo":{"source_id":"tencent","name":"腾讯"},"weMediaInfo":null,"summary":"4月22日，吉利德在公布2024Q1财报的同时，更新了管线进展，其将关于CD47单抗magrolimab的6项试验从管线中剔除。今年2月7日，吉利德宣布，终止magrolimab所有血液瘤项目开发，短短10天后，其又宣布magrolimab实体瘤临床试验遭FDA暂停。而此次6项试验从管线中移除意味着吉利德彻底放弃该款药物的开发。以Magrolimab为代表的CD47靶点曾被认为是下一个重磅炸弹诞生地，然而，该靶点药物开发最终还是以失败告终。","collect":0,"end_time":0,"defaultTopTitle":"qq.com","property":[],"viewcount":null,"language":"zh","relate_stocks":{"LU1585245621.USD":"EASTSPRING INV GLOBAL LOW VOLATILITY EQUITY FUND \"A\" (USD) ACC B","LU1571399168.USD":"ALLSPRING GLOBAL LONG/SHORT EQUITY \"IP\" (USD) ACC","LU0889565916.HKD":"FRANKLIN BIOTECHNOLOGY DISCOVERY \"A\" (HKD) ACC","BK4583":"猴痘概念","BK4532":"文艺复兴科技持仓","LU0234570918.USD":"高盛全球核心股票组合Acc Close","LU1839511570.USD":"WELLS FARGO GLOBAL FACTOR ENHANCED EQUITY \"I\" (USD) ACC","BK4585":"ETF&股票定投概念","BK4139":"生物科技","LU0320765992.SGD":"FTIF - Franklin Biotechnology Discovery A Acc SGD","LU0289739699.SGD":"AB INTERNATIONAL HEALTH CARE PORTFOLIO \"A\" (SGD) ACC","BK4566":"资本集团","LU0109394709.USD":"富兰克林生物科技新领域基金A (acc)","BK4578":"CAR-T","IE00BSNM7G36.USD":"NEUBERGER BERMAN SYSTEMATIC GLOBAL SUSTAINABLE VALUE \"A\" (USD) ACC","LU0058720904.USD":"联博国际健康护理基金A","IE00BZ1G4Q59.USD":"LEGG MASON CLEARBRIDGE US EQUITY SUSTAINABILITY LEADER \"A\"(USD) INC (A)","BK4588":"碎股","BK4550":"红杉资本持仓","BK4568":"美国抗疫概念","LU1066051498.USD":"HSBC GIF GLOBAL EQUITY VOLATILITY FOCUSED \"AM2\" (USD) INC","LU1430594728.SGD":"Eastspring Investments - Global Low Volatility Equity AS SGD","LU1066053197.SGD":"HSBC GIF GLOBAL EQUITY VOLATILITY FOCUSED \"AM3\" (SGDHDG) INC","LU2087621335.USD":"ALLSPRING GLOBAL FACTOR ENHANCED EQUITY \"A\" (USD) ACC","LU2468319806.SGD":"MANULIFE GF HEALTHCARE \"AA\" (SGDHDG) ACC","IE00BKVL7J92.USD":"Legg Mason ClearBridge - US Equity Sustainability Leaders A Acc USD","GILD":"吉利德科学"},"translate_title":"Gilead completely abandons CD47 monoclonal antibody development","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"GILD":0.9},"content_text":"4月22日，吉利德在公布2024Q1财报的同时，更新了管线进展，其将关于CD47单抗magrolimab的6项试验从管线中剔除。包括magrolimab联合疗法治疗头颈部鳞状细胞癌、三阴性乳腺癌、结直肠癌等多种实体瘤研究。今年2月7日，吉利德宣布，终止magrolimab所有血液瘤项目开发，短短10天后，其又宣布magrolimab实体瘤临床试验遭FDA暂停。而此次6项试验从管线中移除意味着吉利德彻底放弃该款药物的开发。Magrolimab是一种潜在的first-in-class抗CD47免疫疗法，由吉利德49亿美元收购Forty Seven公司获得，主要作用机制是阻断CD47-信号调节蛋白（SIRPα）之间的抑制性相互作用，增强巨噬细胞和其他吞噬细胞识别和消灭外来细胞和恶性细胞的能力，从而达到阻断癌细胞发出的“别吃我”信号的目的。以Magrolimab为代表的CD47靶点曾被认为是下一个重磅炸弹诞生地，然而，该靶点药物开发最终还是以失败告终。作为CD47靶点风向标的magrolimab后面还有众多follower，这些项目的未来或许也将迎来变数。处于临床开发阶段的CD47靶向疗法来源：医药魔方NextPharma数据库","kind":null,"is_publish_news":null,"is_publish_highlight":null,"is_publish_live":null,"is_publish_wemedia":null,"editions":null,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"deviceId":"web-server-community-laohu8-v3","version":"4.22.4","shortVersion":"4.22.4","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2430261205"}