“减肥神药”再迎利好！礼来(LLY.US)tirzepatide在治疗睡眠障碍后期试验取得积极结果

智通财经04-17

智通财经APP获悉，礼来(LLY.US)周三宣布，其减肥疗法tirzepatide在针对肥胖和阻塞性睡眠呼吸暂停(OSA)患者的两项三期试验中达到了主要目标。这家制药巨头称，与安慰剂相比，tirzepatide(商品名为Zepbound)显著降低了呼吸暂停低通气指数(AHI)，后者是试验的主要终点。礼来的SURMOUNT-OSA项目涉及多个国家的469名患有中重度OSA和肥胖的成年人，该公司表示，...

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Eli Lilly (LLY.US) tirzepatide achieves positive results in late-stage trial for treating sleep disorders","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"LLY":1},"content_text":"智通财经APP获悉，礼来(LLY.US)周三宣布，其减肥疗法tirzepatide在针对肥胖和阻塞性睡眠呼吸暂停(OSA)患者的两项三期试验中达到了主要目标。这家制药巨头称，与安慰剂相比，tirzepatide(商品名为Zepbound)显著降低了呼吸暂停低通气指数(AHI)，后者是试验的主要终点。礼来的SURMOUNT-OSA项目涉及多个国家的469名患有中重度OSA和肥胖的成年人，该公司表示，该项目也达到了基于AHI百分比变化的关键次要终点。在两项试验中，注射药物在52周时使患者体重减轻了近20%，其中70%的试验对象是男性，与女性相比，他们对tirzepatide等肠促胰岛素治疗的反应较差。礼来表示，大多数不良事件都与胃肠道有关，严重程度一般为轻度至中度。该公司计划从2024年中期开始，将SURMOUNT-OSA数据提交给同行评审期刊，并与包括美国FDA在内的监管机构分享结果。呼吸机设备制造商瑞思迈(RMD.US)、Inspire Medical Systems(INSP.US)、飞利浦(PHG.US)以及睡眠呼吸暂停药物开发商爵士制药(JAZZ.US)可能会受到影响。据了解，凭借FDA批准的GLP-1激动剂，礼来及诺和诺德(NVO.US)在新型减肥药市场占据主导地位。截至发稿，礼来盘前涨2.58%，报766.00美元。","kind":null,"is_publish_news":null,"is_publish_highlight":null,"is_publish_live":null,"is_publish_wemedia":null,"editions":null,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"deviceId":"web-server-community-laohu8-v3","version":"4.22.4","shortVersion":"4.22.4","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2428731027"}