Alnylam(ALNY.US)公布阿尔茨海默病RNAi疗法I期临床积极数据单针持续药效可长达10个月

智通财经2023-10-26

智通财经APP获悉，10月25日，Alnylam Pharmaceuticals(ALNY.US)公布了其RNAi疗法ALN-APP治疗阿尔茨海默病(AD)和脑淀粉样血管病(CAA)的临床I期试验的积极中期结果。试验结果显示，单剂量ALN-APP的持续药效可长达10个月，同时，与AD和CAA相关的淀粉样蛋白片段Aβ42和Aβ40显著降低。ALN-APP是一种靶向淀粉样前体蛋白(APP)的RNAi...

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US) announces phase I clinical positive data of RNAi therapy for Alzheimer's disease. The efficacy of single needle can last up to 10 months","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"ALNY":1},"content_text":"智通财经APP获悉，10月25日，Alnylam Pharmaceuticals(ALNY.US)公布了其RNAi疗法ALN-APP治疗阿尔茨海默病(AD)和脑淀粉样血管病(CAA)的临床I期试验的积极中期结果。试验结果显示，单剂量ALN-APP的持续药效可长达10个月，同时，与AD和CAA相关的淀粉样蛋白片段Aβ42和Aβ40显著降低。ALN-APP是一种靶向淀粉样前体蛋白(APP)的RNAi疗法药物，由Alnylam与Regeneron合作开发。目前，单剂量ALN-APP的进一步探索正在Ia期临床部分进行中。此外，第一名患者现已在Ib期临床部分(多剂量部分)中给药。Ib期临床部分首先在加拿大启动，现在也已获得在英国和荷兰进行所需的所有批准。Alnylam ALN-APP项目负责人Tim Mooney表示：“这些中期数据表明单剂量ALN-APP可以实现深度靶向作用、长时间作用，也进一步说明了RNAi疗法在沉默中枢神经系统(CNS)致病基因方面的潜力。我们会继续进行Ib部分，进一步探索ALN-APP治疗AD和CAA的机会。”","kind":null,"is_publish_news":null,"is_publish_highlight":null,"is_publish_live":null,"is_publish_wemedia":null,"editions":null,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"deviceId":"web-server-community-laohu8-v3","version":"4.22.4","shortVersion":"4.22.4","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2378865854"}

Alnylam(ALNY.US)公布阿尔茨海默病RNAi疗法I期临床积极数据 单针持续药效可长达10个月

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Alnylam(ALNY.US)公布阿尔茨海默病RNAi疗法I期临床积极数据单针持续药效可长达10个月