石药集团(01093)：高选择性PRMT5抑制剂SYH2045获临床试验批准

智通财经2023-01-04

智通财经APP讯，石药集团(01093)公布，集团开发的SYH2045已获得中华人民共和国国家药品监督管理局批准，可以在中国开展用于治疗晚期恶性肿瘤的临床试验。公告称，该产品为具有自主知识产权的化药1类新药，是一种高选择性新型蛋白质精氨酸甲基转移酶5(PRMT5)抑制剂。临床前研究显示，该产品通过抑制组蛋白和非组蛋白上精氨酸的甲基化水平调控基因的转录、mRNA剪接、表达、细胞增殖和分化，抑制肿瘤...

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