Aclaris Therapeutics公布ATI-052一期临床试验积极顶线结果并确立ATI-2138治疗扁平苔藓为首要适应症

美股速递04-28

生物制药公司Aclaris Therapeutics宣布，其潜在首创双特异性抗体ATI-052在1a期健康志愿者临床试验中获得完整的积极顶线人体数据。该候选药物靶向TSLP/IL-4Rα通路，展现良好安全性与药代动力学特征。

同时，该公司明确将口服ITK/JAK3抑制剂ATI-2138的首个适应症聚焦于扁平苔藓治疗。这一战略定位基于该药物在调节T细胞信号通路中的独特机制，为自身免疫性皮肤疾病治疗开辟新路径。

两项进展标志着Aclaris在免疫炎症领域双管齐下的研发布局：ATI-052通过双靶点协同作用阻断炎症级联反应，而ATI-2138则借助口服给药优势精准调控免疫细胞功能。公司计划基于现有数据推进后续临床开发策略。

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Aclaris Therapeutics公布ATI-052一期临床试验积极顶线结果 并确立ATI-2138治疗扁平苔藓为首要适应症

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Aclaris Therapeutics公布ATI-052一期临床试验积极顶线结果并确立ATI-2138治疗扁平苔藓为首要适应症